Journal article
Dsuite - Fast D-statistics and related admixture evidence from VCF files.
- Malinsky M Zoological Institute, University of Basel, Basel, Switzerland.
- Matschiner M Department of Paleontology and Museum, University of Zurich, Zurich, Switzerland.
- Svardal H Department of Biology, University of Antwerp, Antwerp, Belgium.
- 2020-10-04
Published in:
- Molecular ecology resources. - 2020
English
Patterson's D, also known as the ABBA-BABA statistic, and related statistics such as the f4 -ratio, are commonly used to assess evidence of gene flow between populations or closely related species. Currently available implementations often require custom file formats, implement only small subsets of the available statistics, and are impractical to evaluate all gene flow hypotheses across data sets with many populations or species due to computational inefficiencies. Here, we present a new software package Dsuite, an efficient implementation allowing genome scale calculations of the D and f4 -ratio statistics across all combinations of tens or hundreds of populations or species directly from a variant call format (VCF) file. Our program also implements statistics suited for application to genomic windows, providing evidence of whether introgression is confined to specific loci, and it can also aid in interpretation of a system of f4 -ratio results with the use of the "f-branch" method. Dsuite is available at https://github.com/millanek/Dsuite, is straightforward to use, substantially more computationally efficient than comparable programs, and provides a convenient suite of tools and statistics, including some not previously available in any software package. Thus, Dsuite facilitates the assessment of evidence for gene flow, especially across larger genomic data sets.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1111/1755-0998.13265
- PMID 33012121
- Persistent URL
- https://folia.unifr.ch/global/documents/203849
Statistics
Document views: 6
File downloads: