NfL is a biomarker for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.

• Hayer SN From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.
• Krey I From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.
• Barro C From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.
• Rössler F From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.
• Körtvelyessy P From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.
• Lemke JR From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.
• Kuhle J From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.
• Schöls L From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany. ludger.schoels@uni-tuebingen.de.

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Adolescent

Adult

Biomarkers

Case-Control Studies

Female

Heterozygote

Humans

Leukoencephalopathies

Magnetic Resonance Imaging

Male

Mutation

Neurofilament Proteins

Neuroglia

Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

Young Adult