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Journal article

Coregulator-mediated control of skeletal muscle plasticity - A mini-review.

  • Schnyder S Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
  • Kupr B Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
  • Handschin C Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. Electronic address: christoph.handschin@unibas.ch.
  • 2017-01-07
Published in:
  • Biochimie. - 2017
Coregulators
Metabolism
PGC-1
Skeletal muscle
Animals
Histone Acetyltransferases
Histone Deacetylases
Humans
Muscle, Skeletal
Nuclear Receptor Co-Repressor 1
Nuclear Receptor Coactivators
Protein-Arginine N-Methyltransferases
Retinoblastoma Protein
English Skeletal muscle plasticity is a complex process entailing massive transcriptional programs. These changes are mediated by the action of nuclear receptors and other transcription factors. In addition, coregulator proteins have emerged as important players in this process by linking transcription factors to the RNA polymerase II complex and inducing changes in the chromatic structure. An accumulating body of work highlights the pleiotropic functions of coregulator proteins in the control of tissue-specific and whole body metabolism. In skeletal muscle, several coregulators have been identified as potent modulators of metabolic and myofibrillar plasticity. In this mini-review, we will discuss the control, function and physiological significance of these coregulators in skeletal muscle biology.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/202353
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