NEURAPRO: a multi-centre RCT of omega-3 polyunsaturated fatty acids versus placebo in young people at ultra-high risk of psychotic disorders-medium-term follow-up and clinical course.
- Nelson B Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia. Barnaby.Nelson@orygen.org.au.
- Amminger GP Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- Yuen HP Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- Markulev C Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- Lavoie S Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- Schäfer MR Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- Hartmann JA Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- Mossaheb N Department of Psychiatry and Psychotherapy, Clinical Division of Social Psychiatry, Medical University of Vienna, Vienna, Austria.
- Schlögelhofer M Department of Psychiatry, Medical University of Vienna, Vienna, Austria.
- Smesny S University Hospital Jena, Jena, Germany.
- Hickie IB Brain and Mind Research Institute, University of Sydney, Sydney, Australia.
- Berger G Child and Adolescent Psychiatric Service of the Canton of Zurich, Zurich, Switzerland.
- Chen EYH Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong.
- de Haan L Academic Medical Center, Amsterdam, The Netherlands.
- Nieman DH Academic Medical Center, Amsterdam, The Netherlands.
- Nordentoft M Psychiatric Centre Bispebjerg, Copenhagen, Denmark.
- Riecher-Rössler A Psychiatric University Clinics Basel, Basel, Switzerland.
- Verma S Institute of Mental Health, Singapore, Singapore.
- Thompson A Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- Yung AR Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- McGorry PD Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia.
- 2018-06-27
Published in:
- NPJ schizophrenia. - 2018
English
This study reports a medium-term follow-up of a randomised, double-blind, placebo-controlled trial of omega-3 polyunsaturated fatty acids (PUFA) in ultra-high risk for psychosis (UHR) patients. Primary outcomes of interest were transition to psychosis and symptomatic and functional outcome. A secondary aim was to investigate clinical predictors of medium-term outcome. Three hundred four UHR participants were recruited across 10 specialised early psychosis services in Australia, Asia, and Europe. The intervention consisted of 1.4 g/daily of omega-3 PUFA or placebo, plus up to 20 sessions of cognitive-behavioural case management (CBCM), over the 6-month study period, with participants receiving further CBCM sessions on basis of need between months 6-12. Mean time to follow-up was 3.4 (median = 3.3; SD = 0.9) years. There was a modest increase in transitions between 12-month and medium-term follow-up (11-13%) and substantial improvement in symptoms and functioning between baseline and follow-up, with no differences between the treatment groups. Most improvement had been achieved by end of the intervention. 55% of the sample received mental health treatment between end of intervention and follow-up. Omega-3 PUFA did not provide additional benefits to good quality psychosocial intervention over the medium term. Although most improvement had been achieved by end of intervention the substantial rates of post-intervention mental health service use indicate longer-term clinical need in UHR patients. The post-intervention phase treatment or the longer-term effect of CBCM, or a combination of the two, may have contributed to maintaining the gains achieved during the intervention phase and prevented significant deterioration after this time.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1038/s41537-018-0052-x
- PMID 29941938
- Persistent URL
- https://folia.unifr.ch/global/documents/2008
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