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Multifunctional roles for MALT1 in T-cell activation.
Journal article

Multifunctional roles for MALT1 in T-cell activation.

  • Thome M Margot Thome is at the Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland. margot.thomemiazza@unil.ch
  • 2008-06-26
Published in:
  • Nature reviews. Immunology. - 2008
Adaptor Proteins, Signal Transducing
Animals
B-Cell CLL-Lymphoma 10 Protein
Caspases
Humans
Lymphocyte Activation
Lymphoma, B-Cell
Mice
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
NF-kappa B
Neoplasm Proteins
Receptors, Antigen, T-Cell
Signal Transduction
T-Lymphocytes
English The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/20050
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