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Physical methods for gene transfer: improving the kinetics of gene delivery into cells.
Journal article

Physical methods for gene transfer: improving the kinetics of gene delivery into cells.

  • Mehier-Humbert S University of Geneva, School of Pharmacy, CH-1211 Geneva 4, Switzerland. sophie.mehier@brg.bracco.com
  • Guy RH
  • 2005-03-11
Published in:
  • Advanced drug delivery reviews. - 2005
Animals
Cell Membrane
Chemical Phenomena
Chemistry, Physical
Drug Delivery Systems
Electroporation
Genetic Therapy
Humans
Transfection
English One factor critical to successful gene therapy is the development of efficient delivery systems. Although advances in gene transfer technology, including viral and non-viral vectors, have been made, an ideal vector system has not yet been constructed. This review describes the basic principles behind various physical methods for gene transfer and assesses the advantages and performance of such approaches, compared to other transfection systems. In particular, the kinetics and efficiency of gene delivery, the toxicity, in vivo feasibility, and targeting ability of different physical methodologies are discussed and evaluated.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/195754
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