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Biological properties of extracellular vesicles and their physiological functions.
Journal article

Biological properties of extracellular vesicles and their physiological functions.

  • Yáñez-Mó M Unidad de Investigación, Hospital Sta Cristina, Instituto de Investigaciones Sanitarias Princesa (IIS-IP), Madrid, Spain.
  • Siljander PR Extracellular Vesicle Research, Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Helsinki, Finland.
  • Andreu Z Unidad de Investigación, Hospital Sta Cristina, Instituto de Investigaciones Sanitarias Princesa (IIS-IP), Madrid, Spain.
  • Zavec AB Laboratory for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.
  • Borràs FE IVECAT Group - "Germans Trias i Pujol" Research Institute, Badalona, Spain.
  • Buzas EI Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
  • Buzas K Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
  • Casal E Metabolomics Unit, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain.
  • Cappello F Department of Experimental Biomedicine and Clinical Neuroscience, Human Anatomy Section, University of Palermo, Palermo, Italy.
  • Carvalho J Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Colás E Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain.
  • Cordeiro-da Silva A Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Fais S Anti-Tumour Drugs Section, Department of Therapeutic Research and Medicines Evaluation, National Institute of Health (ISS), Rome, Italy.
  • Falcon-Perez JM Metabolomics Unit, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain.
  • Ghobrial IM Dana-Farber Cancer Institute, Boston, MA, USA.
  • Giebel B Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Gimona M Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
  • Graner M Department of Neurosurgery, University of Colorado Denver, CO, USA.
  • Gursel I Department of Molecular Biology and Genetics, Thorlab-Therapeutic Oligonucleotide Research Lab, Bilkent University, Ankara, Turkey.
  • Gursel M Department of Biological Sciences, Middle East Technical University, Ankara, Turkey.
  • Heegaard NH Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
  • Hendrix A Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.
  • Kierulf P Bood Cell Research Group, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
  • Kokubun K Dana-Farber Cancer Institute, Boston, MA, USA.
  • Kosanovic M Department of Immunochemistry and Glycobiology, Institute for the Application of Nuclear Energy, INEP, University of Belgrade, Belgrade, Serbia.
  • Kralj-Iglic V Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia.
  • Krämer-Albers EM Molecular Cell Biology and Focus Program Translational Neurosciences, University of Mainz, Mainz, Germany.
  • Laitinen S Research and Cell Services, Finnish Red Cross Blood Service, Helsinki, Finland.
  • Lässer C Krefting Research Centre, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Lener T Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
  • Ligeti E Department of Physiology, Semmelweis University, Budapest, Hungary.
  • Linē A Latvian Biomedical Research and Study Centre, Riga, Latvia.
  • Lipps G Institute of Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.
  • Llorente A Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital - The Norwegian Radium Hospital, Oslo, Norway.
  • Lötvall J Krefting Research Centre, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Manček-Keber M National Institute of Chemistry, Laboratory of Biotechnology, Ljubljana, Slovenia.
  • Marcilla A Departamento de Biología Celular y Parasitologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain.
  • Mittelbrunn M Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
  • Nazarenko I Institute for Environmental Health Sciences and Hospital Infection ControlMedical Center - University of Freiburg, Freiburg im Breisgau, Germany.
  • Nolte-'t Hoen EN Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Nyman TA Institute of Biotechnology, (Viikinkaari 1), University of Helsinki, Helsinki, Finland.
  • O'Driscoll L School of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Olivan M Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain.
  • Oliveira C Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Pállinger É Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
  • Del Portillo HA ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
  • Reventós J Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain.
  • Rigau M Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain.
  • Rohde E Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
  • Sammar M Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel.
  • Sánchez-Madrid F Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
  • Santarém N Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Schallmoser K Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
  • Ostenfeld MS Departmnet of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
  • Stoorvogel W Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Stukelj R Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia.
  • Van der Grein SG Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • Vasconcelos MH Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Wauben MH Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  • De Wever O Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.
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  • 2015-05-17
Published in:
  • Journal of extracellular vesicles. - 2015
eukaryote
exosome
extracellular vesicle
microparticle
microvesicle
physiology
prokaryote
English In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/193921
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