Journal article
EEG microstates associated with salience and frontoparietal networks in frontotemporal dementia, schizophrenia and Alzheimer's disease.
- Nishida K Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. keiichironishida219@gmail.com
- Morishima Y
- Yoshimura M
- Isotani T
- Irisawa S
- Jann K
- Dierks T
- Strik W
- Kinoshita T
- Koenig T
- 2013-02-14
Published in:
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. - 2013
Adolescent
Adult
Aged
Alzheimer Disease
Brain Mapping
Electroencephalography
Female
Frontal Lobe
Frontotemporal Dementia
Hallucinations
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
Neuropsychological Tests
Parietal Lobe
Schizophrenia
Schizophrenic Psychology
Tomography, Emission-Computed, Single-Photon
Young Adult
English
OBJECTIVE
There are relevant links between resting-state fMRI networks, EEG microstate classes and psychopathological alterations in mental disorders associated with frontal lobe dysfunction. We hypothesized that a certain microstate class, labeled C and correlated with the salience network, was impaired early in frontotemporal dementia (FTD), and that microstate class D, correlated with the frontoparietal network, was impaired in schizophrenia.
METHODS
We measured resting EEG microstate parameters in patients with mild FTD (n = 18), schizophrenia (n = 20), mild Alzheimer's disease (AD; n = 19) and age-matched controls (old n = 19, young n = 18) to investigate neuronal dynamics at the whole-brain level.
RESULTS
The duration of class C was significantly shorter in FTD than in controls and AD, and the duration of class D was significantly shorter in schizophrenia than in controls, FTD and AD. Transition analysis showed a reversed sequence of activation of classes C and D in FTD and schizophrenia patients compared with that in controls, with controls preferring transitions from C to D, and patients preferring D to C.
CONCLUSION
The duration and sequence of EEG microstates reflect specific aberrations of frontal lobe functions in FTD and schizophrenia.
SIGNIFICANCE
This study highlights the importance of subsecond brain dynamics for understanding of psychiatric disorders.
There are relevant links between resting-state fMRI networks, EEG microstate classes and psychopathological alterations in mental disorders associated with frontal lobe dysfunction. We hypothesized that a certain microstate class, labeled C and correlated with the salience network, was impaired early in frontotemporal dementia (FTD), and that microstate class D, correlated with the frontoparietal network, was impaired in schizophrenia.
METHODS
We measured resting EEG microstate parameters in patients with mild FTD (n = 18), schizophrenia (n = 20), mild Alzheimer's disease (AD; n = 19) and age-matched controls (old n = 19, young n = 18) to investigate neuronal dynamics at the whole-brain level.
RESULTS
The duration of class C was significantly shorter in FTD than in controls and AD, and the duration of class D was significantly shorter in schizophrenia than in controls, FTD and AD. Transition analysis showed a reversed sequence of activation of classes C and D in FTD and schizophrenia patients compared with that in controls, with controls preferring transitions from C to D, and patients preferring D to C.
CONCLUSION
The duration and sequence of EEG microstates reflect specific aberrations of frontal lobe functions in FTD and schizophrenia.
SIGNIFICANCE
This study highlights the importance of subsecond brain dynamics for understanding of psychiatric disorders.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.clinph.2013.01.005
- PMID 23403263
- Persistent URL
- https://folia.unifr.ch/global/documents/192481
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