Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
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Pattaro C
Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
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Teumer A
Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.
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Gorski M
Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
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Chu AY
Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA.
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Li M
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
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Mijatovic V
Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, Verona 37134, Italy.
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Garnaas M
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115, USA.
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Tin A
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
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Sorice R
Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, Napoli 80131, Italy.
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Li Y
Department of Internal Medicine IV, University Hospital Freiburg, Berliner Allee 29, Freiburg 79110, Germany.
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Taliun D
Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
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Olden M
Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
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Foster M
Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA.
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Yang Q
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA.
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Chen MH
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA.
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Pers TH
Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
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Johnson AD
NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.
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Ko YA
Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539, USA.
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Fuchsberger C
Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
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Tayo B
Department of Public Health Sciences, Loyola Medical Center, 2160 S First Avenue, Maywood, Illinois 60153, USA.
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Nalls M
Laboratory of Neurogenetics, Building 35-Porter Building, 1A1015, National Institute on Aging/NIH, Bethesda, Maryland 20892, USA.
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Feitosa MF
Division of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108, USA.
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Isaacs A
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Dehghan A
Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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d'Adamo P
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" and University of Trieste, via dell'Istria 65/1, Trieste 34137, Italy.
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Adeyemo A
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635, USA.
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Dieffenbach AK
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
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Zonderman AB
Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, NIH Biomedical Center, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224, USA.
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Nolte IM
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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van der Most PJ
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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Wright AF
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
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Shuldiner AR
Department of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.
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Morrison AC
Human Genetics Center, University of Texas Health Science Center at Houston, 1200 Pressler St Suite 453E, Houston, Texas 77030, USA.
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Hofman A
Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Smith AV
Icelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
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Dreisbach AW
Division of Nephrology, University of Mississippi, 2500 North State Street, Jackson, Mississippi 39216, USA.
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Franke A
Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, Kiel 24105, Germany.
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Uitterlinden AG
Department of Internal Medicine, Erasmus University Medical Center, PO Box 1738, Rotterdam 3000 DR, The Netherlands.
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Metspalu A
Estonian Genome Center of University of Tartu (EGCUT), Riia 23B, Tartu 51010, Estonia.
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Tonjes A
Department of Medicine, University of Leipzig, Liebigstraße 18, Leipzig 04103, Germany.
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Lupo A
Division of Nephrology, Department of Medicine, University of Verona, Piazzale Aristide Stefani 1, Verona 37126, Italy.
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Robino A
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" and University of Trieste, via dell'Istria 65/1, Trieste 34137, Italy.
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Johansson Å
Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.
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Demirkan A
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Kollerits B
Innsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
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Freedman BI
Internal Medicine Department, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053, USA.
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Ponte B
Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital, 4 rue Gabrielle-Perret-Gentil, Geneve 1211, Switzerland.
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Oostra BA
Department of Clinical Genetics, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Paulweber B
First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Müllner Hauptstraße 48, Salzburg 5020, Austria.
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Krämer BK
University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Theodor Kutzer Ufer 1-3, Mannheim 68167, Germany.
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Mitchell BD
Department of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.
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Buckley BM
Department of Pharmacology and Therapeutics, University College Cork, Clinical Investigations Building, Western Rd, Cork, Ireland.
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Peralta CA
Division of Nephrology, University of California, San Francisco Medical School and San Francisco VA Medical Center, 4150 Clement Street, San Francisco, California 94121, USA.
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Hayward C
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
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Helmer C
INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France.
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Rotimi CN
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635, USA.
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Shaffer CM
Vanderbilt University School of Medicine, 2215-B Garland Avenue 1224-MRB4 (Light Hall)Nashville, Tennessee 37232, USA.
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Müller C
University Heart Center Hamburg, Clinic for general and interventional cardiology, Martinistraße 52, Hamburg 20246, Germany.
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Sala C
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
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van Duijn CM
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Dr Molewaterplein 50, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Saint-Pierre A
Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
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Ackermann D
Nephrology Division, Department of Specialties of Internal Medicine, Geneva University Hospital, 4 rue Gabrielle-Perret-Gentil, Geneve 1211, Switzerland.
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Shriner D
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Dr, MSC 5635, Bethesda, Maryland 20892-5635, USA.
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Ruggiero D
Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, Napoli 80131, Italy.
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Toniolo D
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
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Lu Y
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
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Cusi D
Department of Health Sciences, University of Milano, Via Antonio di Rudinì 8, Milano 20142, Italy.
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Czamara D
Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, Munich 80804, Germany.
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Ellinghaus D
Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstraße 12, Kiel 24105, Germany.
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Siscovick DS
Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA.
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Ruderfer D
Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
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Gieger C
Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
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Grallert H
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
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Rochtchina E
Westmead Millennium Institute, Centre for Vision Research, University of Sydney, C24 Westmead Hospital, New South Wales 2145, Australia.
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Atkinson EJ
Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
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Holliday EG
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit, New Lambton New South Wales 2305, Australia.
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Boerwinkle E
Human Genetics Center, University of Texas Health Science Center at Houston, 1200 Pressler St Suite 453E, Houston, Texas 77030, USA.
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Salvi E
Department of Health Sciences, University of Milano, Via Antonio di Rudinì 8, Milano 20142, Italy.
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Bottinger EP
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
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Murgia F
Institute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
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Rivadeneira F
Department of Internal Medicine, Erasmus University Medical Center, PO Box 1738, Rotterdam 3000 DR, The Netherlands.
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Ernst F
Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.
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Kronenberg F
Innsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
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Hu FB
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115, USA.
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Navis GJ
Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands.
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Curhan GC
Brigham and Women's Hospital and Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA.
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Ehret GB
Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, Geneva 1205, Switzerland.
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Homuth G
Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.
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Coassin S
Innsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
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Thun GA
Swiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
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Pistis G
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
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Gambaro G
Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelli University Hospital, Catholic University, Via Moscati 31, Rome 00168, Italy.
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Malerba G
Department of Life and Reproduction Sciences, University of Verona, Strada Le Grazie 8, Verona 37134, Italy.
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Montgomery GW
Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
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Eiriksdottir G
Icelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
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Jacobs G
Institute of Epidemiology and Biobank popgen, Christian-Albrechts University, Niemannsweg 11, Kiel 24105, Germany.
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Li G
Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA.
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Wichmann HE
Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg 85764, Germany.
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Campbell H
Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.
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Schmidt H
Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Department of Neurology, Medical University Graz, Harrachgasse 21, Graz 8010, Austria.
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Wallaschofski H
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475, Germany.
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Völzke H
Institute for Community Medicine, University of Greifswald, Walther-Rathenau-Strasse 48, Greifswald 17487, Germany.
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Brenner H
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
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Kroemer HK
Institute of Pharmacology, University of Greifswald, Friedrich-Loeffler-Straße 23d, Greifswald 17487, Germany.
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Kramer H
Department of Public Health Sciences, Loyola Medical Center, 2160 S First Avenue, Maywood, Illinois 60153, USA.
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Lin H
Boston University School of Medicine, 72 East Concord Street, B-616, Boston, Massachusetts 02118, USA.
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Leach IM
Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30.001, Groningen 9700 RB, The Netherlands.
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Ford I
Robertson Centre for Biostatistics, University of Glasgow, R1122B Level 11, Robertson Centre, Boyd Orr Building, Glasgow G12 8QQ, UK.
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Guessous I
Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland.
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Rudan I
Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.
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Prokopenko I
Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.
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Borecki I
Division of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Boulevard, Box 8506, St Louis, Missouri 63108, USA.
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Heid IM
Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
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Kolcic I
Croatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
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Persico I
Institute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
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Jukema JW
Department of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands.
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Wilson JF
Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.
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Felix JF
Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Divers J
Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063, USA.
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Lambert JC
INSERM U744, Institut Pasteur de Lille, 1 rue du Pr, Calmette, Lille Cédex 59019, France.
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Stafford JM
Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University Health Sciences, 2326 Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063, USA.
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Gaspoz JM
Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland.
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Smith JA
Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029, USA.
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Faul JD
Survey Research Center, Institute for Social Research, University of Michigan, 426 Thompson Street, #3456, Ann Arbor, Michigan 48104, USA.
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Wang JJ
Centre for Vision Research, Westmead Millennium Institute, University of Sydney, C24 Westmead Hospital, New South Wales 2145, Australia.
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Ding J
Wake Forest School of Medicine, Department of Internal Medicine/Geriatrics, Medical center Boulevard, Winston-Salem, North Carolina 27157, USA.
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Hirschhorn JN
Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
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Attia J
Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
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Whitfield JB
Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
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Chalmers J
University of Sydney, The George Institute for Global Health, Level 10, King George V Building, 83-117 Missenden Road, Camperdown, New South Wales 2050, Australia.
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Viikari J
Department of Medicine, University of Turku, Turku University Hospital, PO Box 52, Turku 20521, Finland.
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Coresh J
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
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Denny JC
Vanderbilt University School of Medicine, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212, USA.
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Karjalainen J
Department of Genetics, University of Groningen, University Medical Centre Groningen, PO Box 72, Groningen 9700 AB, The Netherlands.
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Fernandes JK
Division of Endocrinology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425, USA.
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Endlich K
Institute of Anatomy and Cell Biology, University of Greifswald, Friedrich-Loeffler-Straße 23c, Greifswald 17487, Germany.
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Butterbach K
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, Heidelberg 69120, Germany.
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Keene KL
Center for Health Disparities, Department of Biology, East Carolina University, 1001 East 10th Street, N209 Howell Science Complex Mailstop 551, Greenville, North Carolina 27858, USA.
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Lohman K
Internal Medicine Department, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053, USA.
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Portas L
Institute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
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Launer LJ
Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205, USA.
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Lyytikäinen LP
Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere 33520, Finland.
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Yengo L
CNRS UMR 8199, 1 Rue du Professeur Calmette, Lille 59000, France.
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Franke L
Department of Genetics, University of Groningen, University Medical Centre Groningen, PO Box 72, Groningen 9700 AB, The Netherlands.
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Ferrucci L
Clinical Research Branch, National Institute on Aging, 251 Bayview Blvd, Baltimore, Maryland 21250, USA.
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Rose LM
Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA.
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Kedenko L
First Department of Internal Medicine, Paracelsus Medical University/Salzburger Landeskliniken, Müllner Hauptstraße 48, Salzburg 5020, Austria.
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Rao M
Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA.
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Struchalin M
Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Dr Molewaterplein, Rotterdam 50-603015 GE, The Netherlands.
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Kleber ME
Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.
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Cavalieri M
Austrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz, Auenbruggerplatz 22, Graz 8036, Austria.
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Haun M
Innsbruck Medical University, Division of Genetic Epidemiology, Schoepfstraße 41, Innsbruck 6020, Austria.
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Cornelis MC
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, Massachusetts 02115, USA.
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Ciullo M
Institute of Genetics and Biophysics "Adriano Buzzati-Traverso"-CNR, Via P. Castellino 111, Napoli 80131, Italy.
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Pirastu M
Institute of Population Genetics-CNR, Traversa La Crucca 3, 07040 Reg. Baldinca, Li Punti, Sassari, Italy.
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de Andrade M
Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
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McEvoy MA
Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, HRMC, New South Wales 2310, Australia.
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Woodward M
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
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Adam M
Swiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
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Cocca M
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy.
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Nauck M
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, Greifswald 17475, Germany.
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Imboden M
Swiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
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Waldenberger M
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany.
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Pruijm M
Service of Nephrology, Lausanne University Hospital, Rue du Bugnon 17, Lausanne 1005, Switzerland.
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Metzger M
Inserm UMRS 1018, CESP Team 10, Université Paris-Sud, 16 avenue Paul Vaillant Couturier, Villejuif 94807, France.
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Stumvoll M
Department of Medicine, University of Leipzig, Liebigstraße 18, Leipzig 04103, Germany.
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Evans MK
Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, NIH Biomedical Center, 251 Bayview Boulevard, Suite 100, Baltimore, Maryland 21224, USA.
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Sale MM
Center for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia, PO Box 800717, Charlottesville, Virginia 22908, USA.
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Kähönen M
Department of Clinical Physiology, Tampere University Hospital, University of Tampere, School of Medicine, Tampere 33521, Finland.
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Boban M
Croatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
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Bochud M
University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Route de la Corniche 2, Epalinges CH-1066, Switzerland.
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Rheinberger M
Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
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Verweij N
Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30.001, Groningen 9700 RB, The Netherlands.
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Bouatia-Naji N
INSERM UMR970, Paris Cardiovascular Research Center (PARCC), 56 rue Leblanc, Paris F-75015, France.
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Martin NG
Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
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Hastie N
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
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Probst-Hensch N
Swiss Tropical and Public Health Institute, PO Box 4002, Basel, Switzerland.
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Soranzo N
Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK.
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Devuyst O
University of Zurich, Institute of Physiology, Mechanisms of Inherited Kidney Disorders Group, Winterthurerstrasse 190, Zürich 8057, Switzerland.
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Raitakari O
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku University Hospital, Department of Clinical Physiology, PO Box 52, Turku 20521, Finland.
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Gottesman O
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
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Franco OH
Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Polasek O
Croatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
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Gasparini P
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" and University of Trieste, via dell'Istria 65/1, Trieste 34137, Italy.
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Munroe PB
Department Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
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Ridker PM
Harvard Medical School, 900 Commonwealth Avenue East, Boston, Massachusetts 02115, USA.
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Mitchell P
Centre for Vision Research, Westmead Millennium Institute, University of Sydney, C24 Westmead Hospital, New South Wales 2145, Australia.
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Muntner P
University of Alabama at Birmingham, Department of Medicine, 1530 3rd Avenue, South Birmingham, Alabama 35294-0022, USA.
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Meisinger C
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
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Smit JH
Department of Psychiatry and EMGO+ Institute, VU University Medical Center, A.J. Ernststraat 1187, Amsterdam 1081 HL, The Netherlands.
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Kovacs P
Clinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University of Greifswald, Rotgerberstraße 8, Greifswald 17475, Germany.
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Wild PS
Austrian Stroke Prevention Study, Department of Neurology, Division of Special Neurology, Medical University Graz, Auenbruggerplatz 22, Graz 8036, Austria.
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Froguel P
Genetic Epidemiology, Queensland Institute of Medical Research, QIMR, PO Royal Brisbane Hospital, Queensland 4029, Australia.
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Rettig R
Vanderbilt University School of Medicine, 448 Eskind Biomedical Library, 2209 Garland Avenue, Nashville, Tennessee 37212, USA.
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Mägi R
Department of Psychiatry and EMGO+ Institute, VU University Medical Center, A.J. Ernststraat 1187, Amsterdam 1081 HL, The Netherlands.
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Biffar R
School of Biomedical Sciences and Pharmacy, University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, HRMC, New South Wales 2310, Australia.
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Schmidt R
Kidney Research Institute, University of Washington, Box 359606, 325 9th Avenue, Seattle, Washington 98104, USA.
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Middelberg RP
Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.
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Carroll RJ
Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG Scotland, UK.
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Penninx BW
Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029, USA.
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Scott RJ
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65, Trieste 34137, Italy.
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Katz R
NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.
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Sedaghat S
Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.
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Wild SH
Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, Munich 80804, Germany.
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Kardia SL
Department of Cardiology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands.
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Ulivi S
Inserm UMRS 1018, CESP Team 10, Université Paris-Sud, 16 avenue Paul Vaillant Couturier, Villejuif 94807, France.
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Hwang SJ
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, HMRI Building1, Kookaburra Circuit, New Lambton New South Wales 2305, Australia.
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Enroth S
Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
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Kloiber S
Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539, USA.
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Trompet S
INSERM U744, Institut Pasteur de Lille, 1 rue du Pr, Calmette, Lille Cédex 59019, France.
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Stengel B
Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building, 3C309, 7201 Winsconsin Avenue, Bethesda, Maryland 20892-9205, USA.
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Hancock SJ
University Heart Center Hamburg, Clinic for general and interventional cardiology, Martinistraße 52, Hamburg 20246, Germany.
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Turner ST
Croatian Centre for Global Health, University of Split Medical School, Šoltanska 2, Split 21000, Croatia.
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Rosas SE
Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere 33520, Finland.
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Stracke S
Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
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Harris TB
Icelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
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Zeller T
Estonian Genome Center of University of Tartu (EGCUT), Riia 23B, Tartu 51010, Estonia.
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Zemunik T
Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
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Lehtimäki T
Clinical Research Branch, National Institute on Aging, 251 Bayview Blvd, Baltimore, Maryland 21250, USA.
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Illig T
Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.
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Aspelund T
Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Loeffler-Straße 15a, Greifswald 17487, Germany.
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Nikopensius T
Icelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
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Esko T
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
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Tanaka T
Department of Clinical Physiology, Turku University Hospital, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, PO Box 52, Turku 20521, Finland.
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Gyllensten U
Icelandic Heart Association, Research Institute, Holtasmari 1, Kopavogur 201, Iceland.
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Völker U
INSERM U744, Institut Pasteur de Lille, 1 rue du Pr, Calmette, Lille Cédex 59019, France.
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Emilsson V
Center for Public Health Genomics, Department of Medicine (Cardiovascular Medicine), University of Virginia, PO Box 800717, Charlottesville, Virginia 22908, USA.
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Vitart V
Uppsala University, Department of Immunology, Genetics and Pathology, Biomedical Center, SciLifeLab, Uppsala University, Uppsala SE- 75108, Sweden.
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Aalto V
Synlab Academy, Synlab Services GmbH, Oberer Eselsberg 45, Ulm 89081, Germany.
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Gudnason V
Department of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Albert-Einstein-Allee 23, Ulm 89081, Germany.
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Chouraki V
Institute of Epidemiology and Biobank popgen, Christian-Albrechts University, Niemannsweg 11, Kiel 24105, Germany.
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Chen WM
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
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Igl W
Internal Medicine Department, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1053, USA.
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März W
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
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Koenig W
Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), affiliated to the University of Lübeck, Via Galvani 31, Bolzano 39100, Italy.
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Lieb W
University of Maryland Medical School, Division of Nephrology, 685 W. Baltimore Street, MSTF 314, Baltimore, Maryland 21201, USA.
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Loos RJ
Department of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.
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Liu Y
Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 405B Clinical Research Building, Philadelphia, Pennsylvania 19104-4539, USA.
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Snieder H
CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus, 900 Saint-Denis, Montreal, Québec, Canada H2X 0A9.
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Pramstaller PP
CRCHUM, University of Montreal, CHUM Research Center, Technopôle Angus, 900 Saint-Denis, Montreal, Québec, Canada H2X 0A9.
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Parsa A
Kidney Research Institute, University of Washington, Box 359606, 325 9th Avenue, Seattle, Washington 98104, USA.
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O'Connell JR
Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany.
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Susztak K
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, New Research Building77 Avenue Louis Pasteur, Room 458, Boston, Massachusetts 02115, USA.
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Hamet P
Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215, USA.
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Tremblay J
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
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de Boer IH
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
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Böger CA
NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.
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Goessling W
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Chasman DI
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Köttgen A
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Kao WH
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Fox CS
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Published in:
- Nature communications. - 2016
English
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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gold
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https://folia.unifr.ch/global/documents/191370
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