Unexplored therapeutic opportunities in the human genome.
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Oprea TI
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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Bologa CG
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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Brunak S
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Campbell A
IQVIA, Plymouth Meeting, PA, USA.
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Gan GN
UNM Comprehensive Cancer Center, Albuquerque, NM, USA.
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Gaulton A
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Gomez SM
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, USA.
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Guha R
National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
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Hersey A
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Holmes J
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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Jadhav A
National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
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Jensen LJ
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Johnson GL
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
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Karlson A
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Leach AR
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Ma'ayan A
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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Malovannaya A
Baylor College of Medicine, Houston, TX, USA.
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Mani S
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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Mathias SL
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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McManus MT
University of California, San Francisco, CA, USA.
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Meehan TF
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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von Mering C
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
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Muthas D
Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.
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Nguyen DT
National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
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Overington JP
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Papadatos G
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Qin J
Baylor College of Medicine, Houston, TX, USA.
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Reich C
IQVIA, Cambridge, MA, USA.
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Roth BL
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
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Schürer SC
Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA.
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Simeonov A
National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
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Sklar LA
UNM Comprehensive Cancer Center, Albuquerque, NM, USA.
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Southall N
National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
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Tomita S
Yale School of Medicine, Yale University, New Haven, CT, USA.
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Tudose I
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
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Ursu O
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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Vidovic D
Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA.
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Waller A
Center for Molecular Discovery, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM, USA.
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Westergaard D
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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Yang JJ
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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Zahoránszky-Köhalmi G
Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA.
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Published in:
- Nature reviews. Drug discovery. - 2018
English
A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately one out of three proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.
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Language
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Open access status
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green
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Persistent URL
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https://folia.unifr.ch/global/documents/191334
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