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Rapid Polymyxin NP test for the detection of polymyxin resistance mediated by the mcr-1/mcr-2 genes.

  • Poirel L Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland; INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland; Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland.
  • Larpin Y Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland; INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland.
  • Dobias J Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
  • Stephan R Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Zurich, Switzerland.
  • Decousser JW Department of Virology, Bacteriology - Infection Control, Parasitology - Mycology, Assistance Publique - Hôpitaux de Paris, University Hospital Henri Mondor, Créteil, France; IAME, UMR 1137, INSERM, Paris, France.
  • Madec JY Agence Nationale de Sécurité Sanitaire (Anses), Unité Antibiorésistance et Virulence Bactériennes, Lyon, France.
  • Nordmann P Emerging Antibiotic Resistance, Medical and Molecular Microbiology Unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland; INSERM European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland; Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland; Institute for Microbiology, University of Lausanne and University Hospital Centre, Lausanne, Switzerland. Electronic address: patrice.nordmann@unifr.ch.
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  • 2017-11-18
Published in:
  • Diagnostic microbiology and infectious disease. - 2018
Enterobacteriaceae
MCR
Polymyxin
Rapid Polymyxin NP test
Resistance
Animals
Anti-Bacterial Agents
Colistin
Drug Resistance, Bacterial
Enterobacter aerogenes
Enterobacter cloacae
Enterobacteriaceae
Enterobacteriaceae Infections
Escherichia coli
Escherichia coli Proteins
Humans
Klebsiella oxytoca
Klebsiella pneumoniae
Membrane Proteins
Microbial Sensitivity Tests
Polymyxins
beta-Lactamases
English The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR-1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains either recovered from the environment, animals, or humans. Sensitivity and specificity were found to be 100%.
Language
  • English
Open access status
green
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Persistent URL
https://folia.unifr.ch/global/documents/191233
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