Lymphatic vascular morphogenesis in development, physiology, and disease
- Schulte-Merker, Stefan Experimental Zoology Group, Department of Animal Sciences, Wageningen University, 6709 PG Wageningen, Netherlands
- Sabine, Amélie Division of Experimental Oncology, Multidisciplinary Oncology Center, Central University Hospital, and Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
- Petrova, Tatiana V. Division of Experimental Oncology, Multidisciplinary Oncology Center, Central University Hospital, and Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
- 2011-5-16
Published in:
- Journal of Cell Biology. - Rockefeller University Press. - 2011, vol. 193, no. 4, p. 607-618
English
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1083/jcb.201012094
- ISSN 1540-8140
- Persistent URL
- https://folia.unifr.ch/global/documents/19016
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