Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration.
- Garbo C Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Physical Chemistry Centre, Chemical Engineering Department, Cluj-Napoca 400028, Romania.
- Locs J Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga LV-1007, Latvia.
- D'Este M AO Research Institute Davos, Davos Platz 7270, Switzerland.
- Demazeau G HPBioTECH, Leognan 33850, France.
- Mocanu A Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Physical Chemistry Centre, Chemical Engineering Department, Cluj-Napoca 400028, Romania.
- Roman C INCDO INOE 2000, Research Institute for Analytical Instrumentation, Cluj-Napoca 400293, Romania.
- Horovitz O Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Physical Chemistry Centre, Chemical Engineering Department, Cluj-Napoca 400028, Romania.
- Tomoaia-Cotisel M Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Physical Chemistry Centre, Chemical Engineering Department, Cluj-Napoca 400028, Romania.
- 2020-02-28
Published in:
- International journal of nanomedicine. - 2020
bioceramics
characterization
hydroxyapatite
ions release
multi-substituted hydroxyapatites
nanomaterials
synthesis
Biomimetic Materials
Bone Regeneration
Hydroxyapatites
Metals
Nanostructures
Particle Size
Porosity
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
X-Ray Diffraction
English
Purpose
Compositional tailoring is gaining more attention in the development of advanced biomimetic nanomaterials. In this study, we aimed to prepare advanced multi-substituted hydroxyapatites (ms-HAPs), which show similarity with the inorganic phase of bones and might have therapeutic potential for bone regeneration.
Materials
Novel nano hydroxyapatites substituted simultaneously with divalent cations: Mg2+ (1.5%), Zn2+ (0.2%), Sr2+ (5% and 10%), and Si (0.2%) as orthosilicate (SiO4 4-) were designed and successfully synthesized for the first time.
Methods
The ms-HAPs were obtained via a wet-chemistry precipitation route without the use of surfactants, which is a safe and ecologically friendly method. The composition of synthesized materials was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The materials were characterized by X-ray powder diffraction (XRD), FT-IR and FT-Raman spectroscopy, BET measurements and by imaging techniques using high-resolution TEM (HR-TEM), FE-SEM coupled with EDX, and atomic force microscopy (AFM). The ion release was measured in water and in simulated body fluid (SBF).
Results
Characterization methods confirmed the presence of the unique phase of pure stoichiometric HAP structure and high compositional purity of all synthesized nanomaterials. The doping elements influenced the crystallite size, the crystallinity, lattice parameters, morphology, particle size and shape, specific surface area, and porosity. Results showed a decrease in both nanoparticle size and crystallinity degree, coupled with an increase in specific surface area of these advanced ms-HAP materials, in comparison with pure stoichiometric HAP. The release of biologically important ions was confirmed in different liquid media, both in static and simulated dynamic conditions.
Conclusion
The incorporation of the four substituting elements into the HAP structure is demonstrated. Synthesized nanostructured ms-HAP materials might inherit the in vivo effects of substituting functional elements and properties of hydroxyapatite for bone healing and regeneration. Results revealed a rational tailoring approach for the design of a next generation of bioactive ms-HAPs as promising candidates for bone regeneration.
Compositional tailoring is gaining more attention in the development of advanced biomimetic nanomaterials. In this study, we aimed to prepare advanced multi-substituted hydroxyapatites (ms-HAPs), which show similarity with the inorganic phase of bones and might have therapeutic potential for bone regeneration.
Materials
Novel nano hydroxyapatites substituted simultaneously with divalent cations: Mg2+ (1.5%), Zn2+ (0.2%), Sr2+ (5% and 10%), and Si (0.2%) as orthosilicate (SiO4 4-) were designed and successfully synthesized for the first time.
Methods
The ms-HAPs were obtained via a wet-chemistry precipitation route without the use of surfactants, which is a safe and ecologically friendly method. The composition of synthesized materials was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The materials were characterized by X-ray powder diffraction (XRD), FT-IR and FT-Raman spectroscopy, BET measurements and by imaging techniques using high-resolution TEM (HR-TEM), FE-SEM coupled with EDX, and atomic force microscopy (AFM). The ion release was measured in water and in simulated body fluid (SBF).
Results
Characterization methods confirmed the presence of the unique phase of pure stoichiometric HAP structure and high compositional purity of all synthesized nanomaterials. The doping elements influenced the crystallite size, the crystallinity, lattice parameters, morphology, particle size and shape, specific surface area, and porosity. Results showed a decrease in both nanoparticle size and crystallinity degree, coupled with an increase in specific surface area of these advanced ms-HAP materials, in comparison with pure stoichiometric HAP. The release of biologically important ions was confirmed in different liquid media, both in static and simulated dynamic conditions.
Conclusion
The incorporation of the four substituting elements into the HAP structure is demonstrated. Synthesized nanostructured ms-HAP materials might inherit the in vivo effects of substituting functional elements and properties of hydroxyapatite for bone healing and regeneration. Results revealed a rational tailoring approach for the design of a next generation of bioactive ms-HAPs as promising candidates for bone regeneration.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.2147/IJN.S226630
- PMID 32103955
- Persistent URL
- https://folia.unifr.ch/global/documents/189604
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