Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine.
- Wei L Institute of Materials Science and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
- Zhao Y Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
- Hu X Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
- Tang L Institute of Materials Science and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
- 2020-04-02
Published in:
- ACS central science. - 2020
English
A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be copolymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1021/acscentsci.9b01174
- PMID 32232140
- Persistent URL
- https://folia.unifr.ch/global/documents/187279
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