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AMPK in skeletal muscle function and metabolism.
Journal article

AMPK in skeletal muscle function and metabolism.

  • Kjøbsted R Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • Hingst JR Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • Fentz J Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • Foretz M INSERM, Unité 1016, Institut Cochin, Paris, France.
  • Sanz MN Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, and.
  • Pehmøller C Internal Medicine Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, USA.
  • Shum M Axe Cardiologie, Quebec Heart and Lung Research Institute, Laval University, Québec, Canada.
  • Marette A Axe Cardiologie, Quebec Heart and Lung Research Institute, Laval University, Québec, Canada.
  • Mounier R Institute NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM Unité 1217, CNRS UMR, Villeurbanne, France.
  • Treebak JT Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Wojtaszewski JFP Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • Viollet B INSERM, Unité 1016, Institut Cochin, Paris, France.
  • Lantier L Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
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  • 2017-12-16
Published in:
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - 2018
diabetes
exercise
glucose uptake
mitochondria
plasticity
Adaptation, Physiological
Animals
Energy Metabolism
Exercise
Humans
Muscle, Skeletal
Protein Kinases
English Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism ( e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.-Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/185043
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