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A comparative investigation of mussel-mimetic sealants for fetal membrane repair.
Journal article

A comparative investigation of mussel-mimetic sealants for fetal membrane repair.

  • Perrini M Department of Obstetrics, University Hospital Zurich, 8091 Zurich, Switzerland; Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland. Electronic address: perrini@imes.mavt.ethz.ch.
  • Barrett D Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Ochsenbein-Koelble N Department of Obstetrics, University Hospital Zurich, 8091 Zurich, Switzerland.
  • Zimmermann R Department of Obstetrics, University Hospital Zurich, 8091 Zurich, Switzerland.
  • Messersmith P Departments of Bioengineering and Materials Science and Engineering, University of California Berkeley, Berkeley, CA 94720-1760, USA.
  • Ehrbar M Department of Obstetrics, University Hospital Zurich, 8091 Zurich, Switzerland. Electronic address: martin.ehrbar@usz.ch.
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  • 2015-08-10
Published in:
  • Journal of the mechanical behavior of biomedical materials. - 2016
Fetal membrane
Inflation test
Mussel-mimetic sealant
iPPROM
Animals
Biomimetics
Bivalvia
Extraembryonic Membranes
Female
Fetal Membranes, Premature Rupture
Humans
Pregnancy
Tissue Adhesives
English Towards the prevention of iatrogenic preterm premature rupture of the fetal membrane, two mussel-mimetic tissue adhesives (cT and cPEG) have been compared and qualified as possible sealants for membrane repair. Monotonic and cyclic inflation tests of repaired fetal membranes were carried out in order to investigate the performance of the glues under quasi-static, fast, and repeated loading. Finite element simulations of repaired and inflated synthetic membranes allowed to compare cT and cPEG under large deformations. Both adhesives seal the membrane well, resisting pressures higher than the intra-uterine baseline. Only under repeated mechanical load, as well as under fast and acute deformation of the membrane, the sealing performance has deteriorated. Even though cT loses adhesion to the deformed membrane, it is able to withstand high deformations and pressures without rupturing, while cPEG breaks.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/184253
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