Journal article
Two distinct immunopathological profiles in lungs of lethal COVID-19
- Nienhold, Ronny Department of Biomedicine, Experimental Hematology, University Hospital Basel and University of Basel, 4031 Basel, Switzerland
- Ciani, Yari ORCID Laboratory of Computational and Functional Oncology, Department for Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento, Italy
- Koelzer, Viktor ORCID University of Zurich
- Tzankov, Alexandar ORCID University Hospital Basel
- Haslbauer, Jasmin Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
- Menter, Thomas Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
- Schwab, Nathalie Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland
- Henkel, Maurice ORCID Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland
- Frank, Angela Institute of Pathology, Cantonal Hospital Baselland
- Zsikla, Veronika Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland
- Willi, Niels Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland
- Kempf, Werner Kempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland
- Hoyler, Thomas Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland
- Barbareschi, Mattia ORCID U.O. Anatomia Patologica Ospedale S. Chiara
- Moch, Holger University Hospital of Zurich
- Tolnay, Markus University Hospital Basel
- Cathomas, Gieri Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland
- Demichelis, Francesca ORCID University of Trento
- Junt, Tobias Novartis Pharma
- Mertz, Kirsten Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland
English
Abstract
Immune responses in lungs of Coronavirus Disease 2019 (COVID-19) are poorly characterized. We conducted transcriptomic, histologic and cellular profiling of post mortem COVID-19 and normal lung tissues. Two distinct immunopathological reaction patterns were identified. One pattern showed high expression of interferon stimulated genes (ISGs) and cytokines, high viral loads and limited pulmonary damage, the other pattern showed severely damaged lungs, low ISGs, low viral loads and abundant immune infiltrates. Distinct patterns of pulmonary COVID-19 immune responses correlated to hospitalization time and may guide treatment and vaccination approaches.
- Language
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- English
- Open access status
- green
- Identifiers
- Persistent URL
- https://folia.unifr.ch/global/documents/183743
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