Journal article

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

  • Graff M Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Scott RA MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Justice AE Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Young KL Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Feitosa MF Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Barata L Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Winkler TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
  • Chu AY National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Mahajan A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Hadley D Division of Population Health Sciences and Education, St. George's, University of London, London, United Kingdom.
  • Xue L National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Workalemahu T Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
  • Heard-Costa NL National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • den Hoed M MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Ahluwalia TS Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Qi Q Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.
  • Ngwa JS Howard University, Department of Internal Medicine, Washington DC, United States of America.
  • Renström F Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
  • Quaye L Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  • Eicher JD Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Hayes JE Cell and Developmental Biology Graduate Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America.
  • Cornelis M Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
  • Kutalik Z Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
  • Lim E Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
  • Luan J MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Huffman JE National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Zhang W Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Zhao W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Griffin PJ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
  • Haller T Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Ahmad S Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
  • Marques-Vidal PM Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
  • Bien S Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • Yengo L University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
  • Teumer A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Smith AV Icelandic Heart Association, Kopavogur, Iceland.
  • Kumari M ISER, University of Essex, Colchester, Essex, United Kingdom.
  • Harder MN Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Justesen JM Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Kleber ME Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Hollensted M Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lohman K Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
  • Rivera NV Karolinska Institutet, Respiratory Unit, Department of Medicine Solna, Stockholm, Sweden.
  • Whitfield JB Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Zhao JH MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Stringham HM Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Lyytikäinen LP Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  • Huppertz C Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Willemsen G Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Peyrot WJ Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
  • Wu Y Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
  • Kristiansson K National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Demirkan A Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Fornage M Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
  • Hassinen M Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Bielak LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Cadby G Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.
  • Tanaka T Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
  • Mägi R Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • van der Most PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Jackson AU Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Bragg-Gresham JL Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Vitart V MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Marten J MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Navarro P MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Bellis C Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore.
  • Pasko D Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
  • Johansson Å Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Snitker S Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Cheng YC Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Eriksson J Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Lim U Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
  • Aadahl M Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
  • Adair LS Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Amin N Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Balkau B INSERM U-1018, CESP, Renal and Cardiovascular Epidemiology, UVSQ-UPS, Villejuif, France.
  • Auvinen J Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
  • Beilby J Busselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
  • Bergman RN Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
  • Bergmann S Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Bertoni AG Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
  • Blangero J Texas Biomedical Research Institute, San Antonio, Texas, United States of America.
  • Bonnefond A University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
  • Bonnycastle LL Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
  • Borja JB USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.
  • Brage S MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Busonero F Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
  • Buyske S Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America.
  • Campbell H Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
  • Chines PS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
  • Collins FS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
  • Corre T Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Smith GD MRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
  • Delgado GE Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Dueker N University of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of America.
  • Dörr M DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Ebeling T Department of Medicine, Oulu University Hospital, Oulu, Finland.
  • Eiriksdottir G Icelandic Heart Association, Kopavogur, Iceland.
  • Esko T Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Faul JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Fu M Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Færch K Steno Diabetes Center, Gentofte, Denmark.
  • Gieger C Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Gläser S Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
  • Gong J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • Gordon-Larsen P Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Grallert H Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Grammer TB Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Grarup N Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • van Grootheest G Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
  • Harald K National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Hastie ND MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Havulinna AS National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Hernandez D Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America.
  • Hindorff L Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Hocking LJ Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom.
  • Holmens OL St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Holzapfel C Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Hottenga JJ Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Huang J Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.
  • Huang T Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
  • Hui J Busselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
  • Huth C Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Hutri-Kähönen N Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
  • James AL Busselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
  • Jansson JO Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Jhun MA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Juonala M Department of Medicine, University of Turku, Turku, Finland.
  • Kinnunen L National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Koistinen HA National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Kolcic I Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
  • Komulainen P Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Kuusisto J Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Kvaløy K HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
  • Kähönen M Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
  • Lakka TA Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Launer LJ Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Lehne B Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Lindgren CM Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Lorentzon M Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Luben R Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  • Marre M INSERM U-1138, Équipe 2: Pathophysiology and Therapeutics of Vascular and Renal diseases Related to Diabetes, Centre de Recherche des Cordeliers, Paris, France.
  • Milaneschi Y Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
  • Monda KL Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Montgomery GW Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • De Moor MHM EMGO+ Institute, Vrije Universiteit & VU University Medical Center, Amsterdam, The Netherlands.
  • Mulas A Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
  • Müller-Nurasyid M Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Musk AW Busselton Population Medical Research Institute, Nedlands, Western Australia, Australia.
  • Männikkö R Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Männistö S National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Narisu N Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
  • Nauck M DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Nettleton JA Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
  • Nolte IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Oldehinkel AJ Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Olden M Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
  • Ong KK MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Padmanabhan S Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • Paternoster L MRC Integrative Epidemiology Unit & School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
  • Perez J Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
  • Perola M National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Peters A Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Peters U Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • Peyser PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Prokopenko I Genomics of Common Disease, Imperial College London, London, United Kingdom.
  • Puolijoki H South Ostrobothnia Central Hospital, Seinäjoki, Finland.
  • Raitakari OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
  • Rankinen T Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
  • Rasmussen-Torvik LJ Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
  • Rawal R Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Ridker PM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
  • Rose LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
  • Rudan I Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
  • Sarti C Social Services and Health Care Department, City of Helsinki, Helsinki, Finland.
  • Sarzynski MA Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
  • Savonen K Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Scott WR Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Sanna S Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
  • Shuldiner AR Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • Sidney S Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America.
  • Silbernagel G Division of Angiology, Department of Internal Medicine, Medical University Graz, Austria.
  • Smith BH Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • Smith JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Snieder H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Stančáková A Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Sternfeld B Division of Research, Kaiser Permanente Northern California, Oakland, California, United States of America.
  • Swift AJ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
  • Tammelin T LIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland.
  • Tan ST National Heart and Lung Institute, Imperial College London, United Kingdom.
  • Thorand B Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Thuillier D University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
  • Vandenput L Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Vestergaard H Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • van Vliet-Ostaptchouk JV Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Vohl MC Institute of Nutrition and Functional Foods, Quebec, Canada.
  • Völker U DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
  • Waeber G Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
  • Walker M Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Wild S Centre for Population Health Sciences, Usher Institute for Population Health Sciences and Informatics, Teviot Place, Edinburgh, Scotland.
  • Wong A MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
  • Wright AF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Zillikens MC Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Zubair N Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • Haiman CA Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
  • Lemarchand L Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America.
  • Gyllensten U Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Ohlsson C Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Hofman A Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Rivadeneira F Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Uitterlinden AG Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
  • Pérusse L Institute of Nutrition and Functional Foods, Quebec, Canada.
  • Wilson JF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Hayward C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
  • Polasek O Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, Edinburgh, Scotland.
  • Cucca F Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato, Monserrato, Italy.
  • Hveem K HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
  • Hartman CA Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Tönjes A University of Leipzig, Medical Department, Leipzig, Germany.
  • Bandinelli S Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
  • Palmer LJ School of Public Health, University of Adelaide, Adelaide, South Australia, Australia.
  • Kardia SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Rauramaa R Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  • Sørensen TIA Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Tuomilehto J National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Salomaa V National Institute for Health and Welfare, Department of Health, Helsinki, Finland.
  • Penninx BWJH Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ InGeest, Amsterdam, The Netherlands.
  • de Geus EJC Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Boomsma DI Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
  • Lehtimäki T Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  • Mangino M Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
  • Laakso M Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Bouchard C Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
  • Martin NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Kuh D MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
  • Liu Y Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
  • Linneberg A Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
  • März W Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Strauch K Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Kivimäki M Department of Epidemiology and Public Health, University College London, London, United Kingdom.
  • Harris TB Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, Maryland, United States of America.
  • Gudnason V Icelandic Heart Association, Kopavogur, Iceland.
  • Völzke H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Qi L Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
  • Järvelin MR Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Chambers JC Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Kooner JS Department of Cardiology, Ealing Hospital HNS Trust, Middlesex, United Kingdom.
  • Froguel P University of Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, Lille, France.
  • Kooperberg C Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • Vollenweider P Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
  • Hallmans G Department of Biobank Research, Umeå University, Umeå, Sweden.
  • Hansen T Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Pedersen O Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Metspalu A Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Wareham NJ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Langenberg C MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Weir DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Porteous DJ Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • Boerwinkle E Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
  • Chasman DI Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
  • Abecasis GR Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
  • Barroso I Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
  • McCarthy MI Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
  • Frayling TM Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
  • O'Connell JR Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
  • van Duijn CM Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
  • Boehnke M Population Health Research Institute, St. George's University of London, London, United Kingdom.
  • Heid IM Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Mohlke KL Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
  • Strachan DP Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Fox CS Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
  • Liu CT National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Hirschhorn JN Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Klein RJ Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
  • Johnson AD Carolina Center for Genome Sciences, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Borecki IB National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Franks PW MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • North KE MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
  • Cupples LA
  • Loos RJF
  • Kilpeläinen TO
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  • 2017-04-28
Published in:
  • PLoS genetics. - 2017
English Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
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  • English
Open access status
gold
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https://folia.unifr.ch/global/documents/182441
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