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Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study.
Journal article

Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study.

  • Haba-Rubio J From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland. jose.haba-rubio@chuv.ch julius.popp@chuv.ch.
  • Marti-Soler H From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Tobback N From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Andries D From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Marques-Vidal P From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Waeber G From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Vollenweider P From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • von Gunten A From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Preisig M From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Castelao E From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Tafti M From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Heinzer R From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland.
  • Popp J From the Center for Investigation and Research in Sleep (J.H.-R., N.T., D.A., M.T., R.H.), Institute of Social and Preventive Medicine (H.M.-S), Department of Medicine, Service of Internal Medicine (P.M.-V., G.W., P.V.), Department of Psychiatry, Service of Old-Age Psychiatry (A.v.G., J.P.), Department of Psychiatry (M.P., E.C.), Center for Integrative Genomics (M.T.), Department of Clinical Neuroscience, and Leenaards Memory Center (J.P.), Lausanne University Hospital (CHUV) and Lausanne University, Lausanne, Switzerland. jose.haba-rubio@chuv.ch julius.popp@chuv.ch.
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  • 2017-01-01
Published in:
  • Neurology. - 2017
Aged
Cognitive Dysfunction
Follow-Up Studies
Humans
Mental Status Schedule
Multivariate Analysis
Neuropsychological Tests
Polysomnography
Severity of Illness Index
Sleep
Sleep Wake Disorders
Surveys and Questionnaires
Switzerland
English OBJECTIVE
To assess the association between sleep structure and cognitive impairment in the general population.


METHODS
Data stemmed from 580 participants aged >65 years of the population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using validated questionnaires), and a complete polysomnography at home. Cognitive function was evaluated using a comprehensive neuropsychological test battery and a questionnaire on the participant's everyday activities. Participants with cognitive impairment (global Clinical Dementia Rating [CDR] scale score > 0) were compared with participants with no cognitive impairment (global CDR score = 0).


RESULTS
The 291 participants with a CDR score > 0 (72.5 ± 4.6 years), compared to the 289 controls with CDR = 0 (72.1 ± 4.6 years), had significantly more light (stage N1) and less deep (stage N3) and REM sleep, as well as lower sleep efficiency, higher intrasleep wake, and higher sleepiness scores (all p < 0.05). Sleep-disordered breathing was more severe in participants with cognitive impairment with an apnea/hypopnea index (AHI) of 18.0 (7.8-35.5)/h (p50 [p25-p75]) (vs 12.9 [7.2-24.5]/h, p < 0.001), and higher oxygen desaturation index (ODI). In the multivariate analysis after adjustments for confounding variables, the AHI and the ODI ≥4% and ≥6% were independently associated with cognitive impairment.


CONCLUSIONS
Participants aged >65 years with cognitive impairment have higher sleepiness scores and a more disrupted sleep. This seems to be related to the occurrence of sleep-disordered breathing and the associated intermittent hypoxia.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/181671
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