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B Cells and Autoantibodies in Multiple Sclerosis.

  • Pröbstel AK Department of Neurology, University Hospital Basel, Petersgraben 4 & Clinical Neuroimmunology, Hebelstrasse 20, 4031 Basel, Switzerland. anne-katrin.proebstel@usb.ch.
  • Sanderson NS Department of Neurology, University Hospital Basel, Petersgraben 4 & Clinical Neuroimmunology, Hebelstrasse 20, 4031 Basel, Switzerland. nicholas.sanderson@unibas.ch.
  • Derfuss T Department of Neurology, University Hospital Basel, Petersgraben 4 & Clinical Neuroimmunology, Hebelstrasse 20, 4031 Basel, Switzerland. tobias.derfuss@usb.ch.
  • 2015-07-22
Published in:
  • International journal of molecular sciences. - 2015
B cells
autoantibodies
autoantigen
multiple sclerosis
neuromyelitis optica
pathogenesis
therapy
Animals
Autoantibodies
B-Lymphocytes
Humans
Immunotherapy
Multiple Sclerosis
Precision Medicine
English While over the past decades T cells have been considered key players in the pathogenesis of multiple sclerosis (MS), it has only recently become evident that B cells have a major contributing role. Our understanding of the role of B cells has evolved substantially following the clinical success of B cell-targeting therapies and increasing experimental evidence for significant B cell involvement. Rather than mere antibody-producing cells, it is becoming clear that they are team players with the capacity to prime and regulate T cells, and function both as pro- and anti-inflammatory mediators. However, despite tremendous efforts, the target antigen(s) of B cells in MS have yet to be identified. The first part of this review summarizes the clinical evidence and results from animal studies pointing to the relevance of B cells in the pathogenesis of MS. The second part gives an overview of the currently known potential autoantigen targets. The third part recapitulates and critically appraises the currently available B cell-directed therapies.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/18167
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