Journal article
Taking the Brakes Off Targeted Protein Degradation.
- Kozicka Z Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Basel, Switzerland.
- Petzold G Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
- Thomä NH Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. Electronic address: nicolas.thoma@fmi.ch.
- 2020-01-18
Published in:
- Cell chemical biology. - 2020
English
PCSK9 heightens LDL cholesterol levels by chaperoning the liver LDL receptor to lysosomes for degradation. In this issue of Cell Chemical Biology, Petrilli et al. (2020) identify novel PCSK9 ligands and convert them into a proof-of-concept degrader, offering a unique way to modulate this key protein-protein interaction.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.chembiol.2019.12.010
- PMID 31951816
- Persistent URL
- https://folia.unifr.ch/global/documents/17999
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