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Particle interactions of fluticasone propionate and salmeterol xinafoate detected with single particle aerosol mass spectrometry (SPAMS).
Journal article

Particle interactions of fluticasone propionate and salmeterol xinafoate detected with single particle aerosol mass spectrometry (SPAMS).

  • Jetzer MW Novartis Pharma AG - Global Development, Novartis Campus, 4056 Basel, Switzerland; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: martin.jetzer@novartis.com.
  • Morrical BD Novartis Pharma AG - Global Development, Novartis Campus, 4056 Basel, Switzerland.
  • Fergenson DP Livermore Instruments Inc., Oakland, CA 94606, USA.
  • Imanidis G Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland; University of Applied Sciences and Arts Northwestern Switzerland (FHNW), School of Life Sciences, Institute of Pharmaceutical Technology, Gründenstrasse 40, 4132. Muttenz, Switzerland.
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  • 2017-09-03
Published in:
  • International journal of pharmaceutics. - 2017
Dry powder inhaler (DPI)
Particle Co-associations
Particle interactions
Pressurized metered dose inhaler (pMDI)
Single particle aerosol mass spectrometry (SPAMS)
Adrenergic beta-2 Receptor Agonists
Aerosols
Bronchodilator Agents
Dry Powder Inhalers
Fluticasone-Salmeterol Drug Combination
Glucocorticoids
Mass Spectrometry
Metered Dose Inhalers
English Particle co-associations between the active pharmaceutical ingredients fluticasone propionate and salmeterol xinafoate were examined in dry powder inhaled (DPI) and metered dose inhaled (MDI) combination products. Single Particle Aerosol Mass Spectrometry was used to investigate the particle interactions in Advair Diskus® (500/50 mcg) and Seretide® (125/25 mcg). A simple rules tree was used to identify each compound, either alone or co-associated at the level of the individual particle, using unique marker peaks in the mass spectra for the identification of each drug. High levels of drug particle co-association (fluticasone-salmeterol) were observed in the aerosols emitted from Advair Diskus® and Seretide®. The majority of the detected salmeterol particles were found to be in co-association with fluticasone in both tested devices. Another significant finding was that rather coarse fluticasone particles (in DPI) and fine salmeterol particles (both MDI and DPI) were forming the particle co-associations.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/17922
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