Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology.
- Muraro A Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy. Electronic address: muraro@centroallergiealimentari.eu.
- Lemanske RF Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
- Hellings PW Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium.
- Akdis CA Swiss Institute of Allergy and Asthma Research, University of Zurich, Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
- Bieber T Department of Dermatology and Allergy, Christine Kühne-Center for Allergy Research and Education, Friedrich-Wilhelms-University, Bonn, Germany.
- Casale TB Department of Internal Medicine, University of South Florida, Tampa, Fla.
- Jutel M Department of Clinical Immunology, Wrocław Medical University, and ALL-MED Medical Research Institute, Wroclaw, Poland.
- Ong PY Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, and the Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, Calif.
- Poulsen LK Allergy Clinic Copenhagen University Hospital at Gentofte, Copenhagen, Denmark.
- Schmid-Grendelmeier P Allergy Unit, Department for Dermatology, University of Zurich, Zurich, Switzerland, Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
- Simon HU Institute of Pharmacology, University of Bern, Bern, Switzerland.
- Seys SF Laboratory of Clinical Immunology, University of Leuven, Leuven, Belgium.
- Agache I Department of Allergy and Clinical Immunology, Transylvania University, Brasov, Romania.
- 2016-05-08
Published in:
- The Journal of allergy and clinical immunology. - 2016
Precision medicine
allergic asthma
allergic rhinitis
allergic skin disease
biomarker
endotype
personalized care
phenotype
Asthma
Dermatitis, Atopic
Europe
Humans
Precision Medicine
Respiratory System
Rhinitis
Skin
Societies, Scientific
English
In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform. PRACTALL is an initiative of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction, and design of disease-modifying strategies. Progress has been made in profiling the type 2 immune response-driven asthma. The endotype driven approach for non-type 2 immune response asthma, rhinitis, and atopic dermatitis is lagging behind. Validation and qualification of biomarkers are needed to facilitate their translation into pathway-specific diagnostic tests. Wide consensus between academia, governmental regulators, and industry for further development and application of precision medicine in management of allergic diseases is of utmost importance. Improved knowledge of disease pathogenesis together with defining validated and qualified biomarkers are key approaches to precision medicine.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1016/j.jaci.2016.03.010
- PMID 27155030
- Persistent URL
- https://folia.unifr.ch/global/documents/178231
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