Severe acute respiratory distress syndrome (ARDS) induced by human adenovirus B21: Report on 2 cases and literature review.
- Pfortmueller CA Department of Intensive Care, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland. Electronic address: carmen.pfortmueller@insel.ch.
- Barbani MT Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, 3010 Bern, Switzerland. Electronic address: mariateresa.barbani@ifik.unibe.ch.
- Schefold JC Department of Intensive Care, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland. Electronic address: joerg.schefold@insel.ch.
- Hage E Institute of Virology, Hannover Medical School, Hannover, Germany.
- Heim A Institute of Virology, Hannover Medical School, Hannover, Germany. Electronic address: heim.albert@mh-hannover.de.
- Zimmerli S Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, 3010 Bern, Switzerland; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland. Electronic address: stefan.zimmerli@insel.ch.
- 2019-02-25
Published in:
- Journal of critical care. - 2019
Critical illness
HAdV-B21
Respiratory failure
Viral 21B
Adenovirus Infections, Human
Adenoviruses, Human
Adult
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Pneumonia, Viral
Respiratory Distress Syndrome, Adult
English
Severe pneumonia and ARDS caused by human adenovirus B21 infections (HAdV-B21) is a rare, but a devastating disease with rapid progression to multiorgan failure and death. However, only a few cases were reported so far. Infections appear associated with increased disease severity and higher mortality in infected critically ill patients. Possible factors contributing to infection are underlying psychiatric disease resulting in institutionalization of respective patients, and polytoxicomania. Controlled data on the therapy of severe adenovirus infections are lacking and remains experimental. In conclusion, data on HAdV-B21 infections causing severe pneumonia or ARDS are scarce. Controlled clinical trials on the therapy of adenovirus pneumonia are non existent and thus there is no established therapy so far. ICU physicians should be aware of this potentially devastating disease and further studies are needed.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.jcrc.2019.02.019
- PMID 30798099
- Persistent URL
- https://folia.unifr.ch/global/documents/178081
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