High-Density Mapping of Brain Slices using a Large Multi-Functional High-Density CMOS Microelectrode Array System.
- Viswam V Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- Bounik R Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- Shadmani A Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- Dragas J Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- Obien M Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- Müller J Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- Chen Y Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- Hierlemann A Bio Engineering Laboratory, ETH Zurich, Basel, Switzerland.
- 2017-09-05
Published in:
- International Solid-State Sensors, Actuators and Microsystems Conference : [proceedings]. International Conference on Solid-State Sensors, Actuators, and Microsystems. - 2017
Action potential
Brain slices
CMOS
Electrophysiology
High-density microelectrode arrays
Impedance measurement
English
We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm2 array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm2). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement and 28 neurotransmitter-detection channels and 16 voltage/current stimulation channels. The system enables real-time and label-free monitoring of position, size, morphology and electrical activity of brain slices.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1109/TRANSDUCERS.2017.7994006
- PMID 28868212
- Persistent URL
- https://folia.unifr.ch/global/documents/176308
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