Back
Etiology and Pathogenesis of Psoriasis.
Journal article

Etiology and Pathogenesis of Psoriasis.

  • Boehncke WH Department of Dermatology and Venereology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, Genève 14 CH - 1211, Switzerland; Department of Pathology and Immunology, University of Geneva, Rue Michel-Servet 7, Geneva CH - 1206, Switzerland. Electronic address: wolf-henning.boehncke@hcuge.ch.
  • 2015-10-18
Published in:
  • Rheumatic diseases clinics of North America. - 2015
Dendritic cells
Etiology
Genome-wide association study
IL-17
Keratinocytes
Pathogenesis
Psoriasis
T lymphocytes
Adaptive Immunity
Cytokines
Humans
Inflammation
Psoriasis
Skin
English Psoriasis is a common, chronic inflammatory skin disease most often appearing in the form of well-demarcated, scaly plaques. These lesions highlight the fundamental processes underlying its pathogenesis, namely, inflammation and epidermal hyperproliferation. Both phenomena are considered consequences of an intimate interplay between the innate and the adaptive immune system. This concept is supported by results of genetic studies, pointing toward the signaling pathways of nuclear factor-κB, interferon-γ, and interleukin (IL)-23 as well as antigen presentation as central axes of the psoriatic inflammation. Efficacy of biologics targeting tumor necrosis factor-α, IL-23, or IL-17 provides further evidence in favor of this model.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/174806
Statistics
Document views: 24 File downloads: