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Hepatocyte growth factor: A regulator of inflammation and autoimmunity.
Journal article

Hepatocyte growth factor: A regulator of inflammation and autoimmunity.

  • Molnarfi N Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva, Geneva, Switzerland.
  • Benkhoucha M Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva, Geneva, Switzerland.
  • Funakoshi H Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa, Japan.
  • Nakamura T Neurogen Inc., Nakahozumi, Ibaraki, Osaka, Japan.
  • Lalive PH Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva, Geneva, Switzerland; Department of Genetics and Laboratory Medicine, Laboratory Medicine Service, University Hospital of Geneva, Geneva, Switzerland. Electronic address: patrice.lalive@hcuge.ch.
  • 2014-12-06
Published in:
  • Autoimmunity reviews. - 2015
Autoimmune regulator
Autoimmunity
HGF
Inflammation
Therapy
c-Met
Animals
Autoimmunity
Hepatocyte Growth Factor
Humans
Inflammation
Signal Transduction
English Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/174620
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