Non-antioxidant molecular functions of alpha-tocopherol (vitamin E).
- Azzi A Institute of Biochemistry and Molecular Biology, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland. angelo.azzi@mci.unibe.ch
- Ricciarelli R
- Zingg JM
- 2002-05-23
Published in:
- FEBS letters. - 2002
Animals
CD36 Antigens
Carrier Proteins
Cell Adhesion
Enzyme Activation
Gene Expression Regulation
Humans
Membrane Proteins
Muscle, Smooth, Vascular
Platelet Aggregation
Protein Kinase C
Receptors, Immunologic
Receptors, Lipoprotein
Receptors, Scavenger
Scavenger Receptors, Class A
Scavenger Receptors, Class B
Vitamin E
English
alpha-Tocopherol (the major vitamin E component) regulates key cellular events by mechanisms unrelated with its antioxidant function. Inhibition of protein kinase C (PKC) activity and vascular smooth muscle cell growth by alpha-tocopherol was first described by our group. Later, alpha-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages. alpha-Tocopherol diminishes adhesion molecule, collagenase and scavenger receptor (SR-A and CD36) expression and increases connective tissue growth factor expression.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/s0014-5793(02)02706-0
- PMID 12023009
- Persistent URL
- https://folia.unifr.ch/global/documents/172230
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