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The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer.

  • Häfliger P Institute of Biochemistry and Molecular Medicine, and Swiss National Center of Competence in Research (NCCR) TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland. ph2548@cumc.columbia.edu.
  • Charles RP Institute of Biochemistry and Molecular Medicine, and Swiss National Center of Competence in Research (NCCR) TransCure, University of Bern, Bühlstrasse 28, CH-3012 Bern, Switzerland. roch-philippe.charles@ibmm.unibe.ch.
  • 2019-05-19
Published in:
  • International journal of molecular sciences. - 2019
cancer
inhibitor
l-type amino acid transporter LAT1
preclinical studies
targeted therapy
Amino Acid Transport System y+L
Amino Acids
Biological Transport
Cell Proliferation
Drug Discovery
Humans
Large Neutral Amino Acid-Transporter 1
Nanoparticles
Neoplasm Proteins
Neoplasms
English Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are indispensable for proliferating cancer cells. Their uptake across the cell membrane is tightly controlled by membrane transporters. Among those, the L-type amino acid transporter LAT1 (SLC7A5) has been repeatedly found overexpressed in a vast variety of cancers. In this review, we summarize the most recent advances in our understanding of the role of LAT1 in cancer and highlight preclinical studies and drug developments underlying the potential of LAT1 as therapeutic target.
Language
  • English
Open access status
gold
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Persistent URL
https://folia.unifr.ch/global/documents/169941
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