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Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study.
Journal article

Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study.

  • Babiloni C Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: claudio.babiloni@uniroma1.it.
  • Del Percio C Department of Integrated Imaging, IRCCS SDN, Naples, Italy.
  • Lizio R Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy.
  • Noce G Department of Integrated Imaging, IRCCS SDN, Naples, Italy.
  • Cordone S Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy.
  • Lopez S Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy.
  • Soricelli A Department of Integrated Imaging, IRCCS SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy.
  • Ferri R Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
  • Pascarelli MT Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Italy.
  • Nobili F Department of Neuroscience (DiNOGMI), Clinical Neurology, University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy.
  • Arnaldi D Department of Neuroscience (DiNOGMI), Clinical Neurology, University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy.
  • Aarsland D Department of Old Age Psychiatry, King's College University, London, UK.
  • Orzi F Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy.
  • Buttinelli C Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy.
  • Giubilei F Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy.
  • Onofrj M Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.
  • Stocchi F Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy.
  • Stirpe P Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy.
  • Fuhr P Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland.
  • Gschwandtner U Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland.
  • Ransmayr G Department of Neurology and Psychiatry and Faculty of Medicine, Johannes Kepler University Linz, General Hospital of the City of Linz, Linz, Austria.
  • Caravias G Department of Neurology and Psychiatry and Faculty of Medicine, Johannes Kepler University Linz, General Hospital of the City of Linz, Linz, Austria.
  • Garn H AIT Austrian Institute of Technology GmbH, Vienna, Austria.
  • Sorpresi F Hospital San Raffaele of Cassino, Cassino, Italy.
  • Pievani M Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
  • Frisoni GB Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
  • D'Antonio F Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
  • De Lena C Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy.
  • Güntekin B Department of Biophysics, Istanbul Medipol University, Istanbul, Turkey.
  • Hanoğlu L Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey.
  • Başar E Department of Neurosciences, Dokuz Eylül University Medical School, Izmir, Turkey; Department of Neurology, Dokuz Eylül University Medical School, Izmir, Turkey.
  • Yener G Department of Psychology, Dokuz Eylül University, Izmir, Turkey; Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.
  • Emek-Savaş DD Department of Psychology, Dokuz Eylül University, Izmir, Turkey; Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.
  • Triggiani AI Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  • Franciotti R Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.
  • De Pandis MF Hospital San Raffaele of Cassino, Cassino, Italy.
  • Bonanni L Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.
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  • 2017-04-30
Published in:
  • Neurobiology of aging. - 2017
Alzheimer's disease dementia (ADD)
Dementia with Lewy body (DLB)
Exact low-resolution brain electromagnetic source tomography (eLORETA)
Parkinson's disease dementia (PDD)
Resting state electroencephalographic (rsEEG) rhythms
Aged
Alzheimer Disease
Cerebral Cortex
Cortical Synchronization
Electroencephalography
Female
Humans
Lewy Body Disease
Male
Ocular Physiological Phenomena
Rest
Retrospective Studies
English The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85-0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/169497
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