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Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis.
Journal article

Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis.

  • Gabriel D Apidel SA, 29 Quai du Mont Blanc, 1201 Geneva, Switzerland. Electronic address: doris00gabriel@gmail.com.
  • Mugnier T Apidel SA, 29 Quai du Mont Blanc, 1201 Geneva, Switzerland.
  • Courthion H Apidel SA, 29 Quai du Mont Blanc, 1201 Geneva, Switzerland.
  • Kranidioti K Biomedcode Hellas SA, 34 Al Fleming Street, 16672 Vari, Athens, Greece.
  • Karagianni N Biomedcode Hellas SA, 34 Al Fleming Street, 16672 Vari, Athens, Greece.
  • Denis MC Biomedcode Hellas SA, 34 Al Fleming Street, 16672 Vari, Athens, Greece.
  • Lapteva M School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, CMU-1, Rue Michel Servet, 1211 Geneva 4, Switzerland.
  • Kalia Y School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, CMU-1, Rue Michel Servet, 1211 Geneva 4, Switzerland.
  • Möller M Apidel SA, 29 Quai du Mont Blanc, 1201 Geneva, Switzerland.
  • Gurny R Apidel SA, 29 Quai du Mont Blanc, 1201 Geneva, Switzerland.
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  • 2016-09-19
Published in:
  • Journal of controlled release : official journal of the Controlled Release Society. - 2016
Dermatology
Hydrogel
Immune-mediated skin disease
Methoxy poly (ethylen glycol) hexyl-substituted poly (lactic acid)
Polymeric nanocarriers
Skin topical drug delivery
Tacrolimus
Administration, Cutaneous
Aminoquinolines
Animals
Biological Availability
Chemistry, Pharmaceutical
Disease Models, Animal
Drug Carriers
Drug Delivery Systems
Hydrogels
Imiquimod
Immunosuppressive Agents
Mice
Mice, Inbred C57BL
Polymers
Psoriasis
Skin
Skin Absorption
Solubility
Tacrolimus
English We have developed a composite hydrogel for improved topical delivery of the poorly soluble drug Tacrolimus (TAC) to psoriasis lesions. TAC is efficiently solubilized in methoxy poly- (ethylene glycol) hexyl substituted poly-(lactic acid) (mPEGhexPLA) based nanocarriers. For convenient and patient-friendly topical administration, TAC loaded polymeric nanocarriers were incorporated in a Carbopol® based hydrogel, to yield a composite hydrogel formulation (TAC composite hydrogel). TAC composite hydrogel was designed to have superior pharmaceutical formulation properties, delivery efficiency and local bioavailability, compared to currently available paraffin-based TAC ointments. Composite hydrogel formulations had good local tolerance and showed no signs of immediate toxicity after repeated topical administration in healthy mice. Skin delivery of TAC composite hydrogel in an imiquimod-induced psoriasis mouse model was found to be twice as high as for the commercial formulation Protopic™, used as benchmark. TAC composite hydrogel showed significant improvement in the in vivo and histopathological features of the imiquimod-induced psoriasis model.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/169346
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