EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study).
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Lam TBL
Academic Urology Unit, University of Aberdeen, Aberdeen, UK; Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK. Electronic address: thomas.lam@nhs.net.
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MacLennan S
Academic Urology Unit, University of Aberdeen, Aberdeen, UK.
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Willemse PM
Department of Urology, University Medical Center Utrecht, Utrecht, The Netherlands.
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Mason MD
Division of Cancer and Genetics, School of Medicine Cardiff University, Velindre Cancer Centre, Cardiff, UK.
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Plass K
EAU Guidelines Office, Arnhem, The Netherlands.
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Shepherd R
EAU Guidelines Office, Arnhem, The Netherlands.
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Baanders R
Oxford, UK.
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Bangma CH
Department of Urology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
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Bjartell A
Department of Urology, Skåne University Hospital Malmö, Lund University, Lund, Sweden.
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Bossi A
Department of Radiation Oncology, Gustave Roussy Institute, Villejuif, France.
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Briers E
Hasselt, Belgium.
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Briganti A
Department of Urology, Scientific Institute and University Vita-Salute San Raffaele Hospital, Milan, Italy.
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Buddingh KT
HagaZiekenhuis, The Hague, The Netherlands.
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Catto JWF
Academic Urology Unit, University of Sheffield, Sheffield, UK; Department of Urology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
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Colecchia M
Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
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Cox BW
Department of Radiation Medicine, Zucker School of Medicine, Hempstead, New York, NY, USA.
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Cumberbatch MG
Academic Urology Unit, University of Sheffield, Sheffield, UK.
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Davies J
Wales, UK.
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Davis NF
Department of Urology, Beaumont and Connolly Hospitals, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
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De Santis M
Department of Urology, Charité University Hospital, Berlin, Germany.
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Dell'Oglio P
Unit of Urology, Division of Oncology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; ORSI Academy, Melle, Belgium.
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Deschamps A
Europa Uomo, Antwerp, Belgium.
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Donaldson JF
Academic Urology Unit, University of Aberdeen, Aberdeen, UK; Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK.
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Egawa S
Asian School of Urology, UAA, Jikei University School of Medicine, Tokyo, Japan.
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Fankhauser CD
Department of Urology, University of Zurich, Zurich, Switzerland.
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Fanti S
Department of Nuclear Medicine, Policlinico S. Orsola, University of Bologna, Italy.
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Fossati N
Department of Urology, Scientific Institute and University Vita-Salute San Raffaele Hospital, Milan, Italy.
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Gandaglia G
Unit of Urology, Division of Oncology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
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Gillessen S
Division of Cancer Sciences, University of Manchester and The Christie, Manchester, UK; Department of Medical Oncology and Haematology, Cantonal Hospital St. Gallen, University of Bern, Bern, Switzerland.
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Grivas N
Department of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
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Gross T
Department of Urology, University of Bern, Bern, Switzerland.
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Grummet JP
Department of Surgery, Central Clinical School, Monash University, Melbourne, Australia.
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Henry AM
Leeds Cancer Centre, St. James's University Hospital, Leeds, UK.
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Ingels A
Department of Urology, Henri Mondor Hospital, Créteil, France.
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Irani J
University Hospital of Bicêtre-Paris Sud-Saclay University, Le Kremlin Bicêtre, France.
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Lardas M
Department of Reconstructive Urology and Surgical Andrology, Metropolitan General, Athens, Greece.
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Liew M
Department of Urology, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UK.
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Lin DW
Cancer Prevention Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Urology, University of Washington, Seattle, WA, USA.
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Moris L
Department of Urology, University Hospitals Leuven, Leuven, Belgium; Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium.
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Omar MI
Academic Urology Unit, University of Aberdeen, Aberdeen, UK.
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Pang KH
Academic Urology Unit, University of Sheffield, Sheffield, UK.
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Paterson CC
Academic Urology Unit, University of Aberdeen, Aberdeen, UK; University of Canberra, School of Nursing, Midwifery and Public Health, Canberra, Australia; Robert Gordon University, School of Nursing and Midwifery, Aberdeen, UK.
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Renard-Penna R
Academic Department of Radiology, Sorbonne Université, GRC no 5, ONCOTYPE-URO, AP-HP, Hôpital Pitié-Salpêtrière-Hôpital Tenon, Paris, France.
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Ribal MJ
Uro-Oncology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.
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Roobol MJ
Department of Urology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
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Rouprêt M
Urology Department, Sorbonne Université, GRC no 5, ONCOTYPE-URO, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.
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Rouvière O
Hospices Civils de Lyon, Department of Urinary and Vascular Imaging, Hôpital Edouard Herriot, Lyon, France; Université de Lyon, Université Lyon 1, Faculté de Médecine Lyon Est, Lyon, France.
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Sancho Pardo G
Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
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Richenberg J
Royal Sussex County Hospital Brighton and Brighton and Sussex Medical School, Brighton, Sussex, UK.
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Schoots IG
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
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Sedelaar JPM
Department of Urology, Radboud University Medical Centre, Nijmegen, The Netherlands.
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Stricker P
Department of Urology, St Vincents Hospital and Campus, Sydney, Australia; Garvan Institute of Research, Sydney, Australia.
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Tilki D
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
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Vahr Lauridsen S
Department of Urology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
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van den Bergh RCN
Department of Urology, St. Antonius Hospital, Utrecht, The Netherlands.
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Van den Broeck T
Department of Urology, University Hospitals Leuven, Leuven, Belgium.
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van der Kwast TH
Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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van der Poel HG
Department of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
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van Leenders GJLH
Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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Varma M
Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK.
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Violette PD
Departments of Health Research Methods, Evidence and Impact (HEI) and Surgery, McMaster University, Hamilton, ON, Canada.
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Wallis CJD
Division of Urology, Department of Surgery, University of Toronto, Toronto, ON, Canada; Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
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Wiegel T
Department of Radiation Oncology, University Hospital Ulm, Ulm, Germany.
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Wilkinson K
University College London Hospitals, London, UK.
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Zattoni F
Urology Unit, Academic Medical Centre Hospital, Udine, Italy.
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N'Dow JMO
Academic Urology Unit, University of Aberdeen, Aberdeen, UK; Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK.
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Van Poppel H
Department of Urology, University Hospitals Leuven, Leuven, Belgium.
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Cornford P
Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool, UK.
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Mottet N
Department of Urology, University Hospital Jean Monnet, St. Etienne, France.
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English
BACKGROUND
There is uncertainty in deferred active treatment (DAT) programmes, regarding patient selection, follow-up and monitoring, reclassification, and which outcome measures should be prioritised.
OBJECTIVE
To develop consensus statements for all domains of DAT.
DESIGN, SETTING, AND PARTICIPANTS
A protocol-driven, three phase study was undertaken by the European Association of Urology (EAU)-European Association of Nuclear Medicine (EANM)-European Society for Radiotherapy and Oncology (ESTRO)-European Association of Urology Section of Urological Research (ESUR)-International Society of Geriatric Oncology (SIOG) Prostate Cancer Guideline Panel in conjunction with partner organisations, including the following: (1) a systematic review to describe heterogeneity across all domains; (2) a two-round Delphi survey involving a large, international panel of stakeholders, including healthcare practitioners (HCPs) and patients; and (3) a consensus group meeting attended by stakeholder group representatives. Robust methods regarding what constituted the consensus were strictly followed.
RESULTS AND LIMITATIONS
A total of 109 HCPs and 16 patients completed both survey rounds. Of 129 statements in the survey, consensus was achieved in 66 (51%); the rest of the statements were discussed and voted on in the consensus meeting by 32 HCPs and three patients, where consensus was achieved in additional 27 statements (43%). Overall, 93 statements (72%) achieved consensus in the project. Some uncertainties remained regarding clinically important thresholds for disease extent on biopsy in low-risk disease, and the role of multiparametric magnetic resonance imaging in determining disease stage and aggressiveness as a criterion for inclusion and exclusion.
CONCLUSIONS
Consensus statements and the findings are expected to guide and inform routine clinical practice and research, until higher levels of evidence emerge through prospective comparative studies and clinical trials.
PATIENT SUMMARY
We undertook a project aimed at standardising the elements of practice in active surveillance programmes for early localised prostate cancer because currently there is great variation and uncertainty regarding how best to conduct them. The project involved large numbers of healthcare practitioners and patients using a survey and face-to-face meeting, in order to achieve agreement (ie, consensus) regarding best practice, which will provide guidance to clinicians and researchers.
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Open access status
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bronze
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Persistent URL
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https://folia.unifr.ch/global/documents/167345
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