Tissue engineering and regenerative approaches to improving the healing of large bone defects.
- Verrier S AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland.sophie.verrier@aofoundation.org.
- Alini M
- Alsberg E
- Buchman SR
- Kelly D
- Laschke MW
- Menger MD
- Murphy WL
- Stegemann JP
- Schütz M
- Miclau T
- Stoddart MJ
- Evans C
- 2016-07-20
Published in:
- European cells & materials. - 2016
Animals
Bone Regeneration
Bone and Bones
Drug Delivery Systems
Genetic Therapy
Humans
Tissue Engineering
Tissue Scaffolds
English
Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and remain a clinical challenge. Healing such defects requires the formation of large amounts of bone in an environment often rendered hostile to osteogenesis by damage to the surrounding soft tissues and vasculature. In recent years, there have been intensive research efforts directed towards tissue engineering and regenerative approaches designed to overcome this multifaceted challenge. In this paper, we describe and critically evaluate the state-of-the-art approaches to address the various components of this intricate problem. The discussion includes (i) the properties of synthetic and natural scaffolds, their use in conjunction with cell and growth factor delivery, (ii) their vascularisation, (iii) the potential of gene therapies and (iv) the role of the mechanical environment. In particular, we present a critical analysis of where the field stands, and how it can move forward in a coordinated fashion.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.22203/ecm.v032a06
- PMID 27434267
- Persistent URL
- https://folia.unifr.ch/global/documents/164269
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