Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder.
- Walitza S University Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland; Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Germany; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Switzerland. Electronic address: Susanne.Walitza@kjpdzh.ch.
- Marinova Z University Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland. Electronic address: zoya.marinova@kjpdzh.ch.
- Grünblatt E University Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Switzerland; Department of Psychiatry, Psychosomatic and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
- Lazic SE In Silico Lead Discovery, Novartis Institutes for Biomedical Research, Basel, Switzerland.
- Remschmidt H Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, Germany.
- Vloet TD Department of Child and Adolescent Psychiatry and Psychotherapy, Technical University of Aachen, Germany.
- Wendland JR Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA.
- 2014-08-06
Published in:
- Neuroscience letters. - 2014
5-HTTLPR
Meta-analysis
Obsessive–compulsive disorder
Serotonin transporter
Transmission disequilibrium test
Adult
Age of Onset
Child
Genetic Association Studies
Genetic Predisposition to Disease
Genetic Variation
Humans
Obsessive-Compulsive Disorder
Serotonin Plasma Membrane Transport Proteins
English
Despite compelling evidence for major genetic contributions to the etiology of obsessive-compulsive disorder (OCD), few genetic variants have been consistently associated with this debilitating illness. Molecular genetic studies in children and adolescents with OCD are of particular interest, since early onset of the disease has been observed to be associated with increased familiality. We replicate here for the first time in early-onset OCD patients, a previously reported association of OCD with the common gain-of-function LA allele at the serotonin transporter linked polymorphic region known as 5-HTTLPR in a collection of parent-offspring trios. The present meta-analysis of this recently refined serotonin transporter gene variant revealed further support for the LA allele conferring increased genetic susceptibility to OCD. We conclude that the 5-HTTLPR is currently the single best supported risk variant for OCD, in regards of early-onset OCD, albeit of modest effect size and the possibility that the conferred risk might not be specific to OCD.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.neulet.2014.07.038
- PMID 25093702
- Persistent URL
- https://folia.unifr.ch/global/documents/158219
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