European trends in epilepsy surgery.
Journal article

European trends in epilepsy surgery.

  • Baud MO From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Perneger T From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Rácz A From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Pensel MC From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Elger C From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Rydenhag B From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Malmgren K From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Cross JH From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • McKenna G From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Tisdall M From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Lamberink HJ From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Rheims S From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Ryvlin P From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Isnard J From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Mauguière F From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Arzimanoglou A From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Akkol S From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Deniz K From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Ozkara C From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Lossius M From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Rektor I From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Kälviäinen R From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Vanhatalo LM From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Dimova P From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Minkin K From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Staack AM From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Steinhoff BJ From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Kalina A From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Krsek P From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Marusic P From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Jordan Z From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Fabo D From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Carrette E From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Boon P From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Rocka S From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Mameniškienė R From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Vulliemoz S From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Pittau F From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Braun KPJ From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania.
  • Seeck M From the Department of Neurology (M.O.B., S.V., F.P., M.S.), and Center for Clinical Research (T.P.), University Hospital Geneva; Department of Neurology (M.O.B.), University Hospital Bern; Wyss Center for Bio- and Neuro-Engineering (M.O.B.), Geneva, Switzerland; Klinik und Poliklinik für Epileptologie (A.R., M.C.P., C.E.), Universitätsklinikum Bonn, Germany; Sahlgrenska University Hospital and Sahlgrenska Academy at the University of Gothenburg (B.R., K. Malmgren), Sweden; UCL Great Ormond Street Hospital (J.H.C., G.M., M.T.), London, UK; Department of Child Neurology (H.J.L., K.P.J.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Functional Neurology and Epileptology (S. Rheims, J.I., P.R., F.M.) and Department of Clinical Epileptology, Sleep Disorders, and Functional Neurology in Children (A.A., P.R.), Hospices Civils de Lyon and University of Lyon, France; Department of Neurology (P.R.), University Hospital Lausanne, Switzerland; Department of Neurology (S.A., K.D., C.O.), Cerrahpasa Medical Faculty, Istanbul University, Turkey; Clinic for Neuroscience (M.L.), National Center for Epilepsy, Oslo University Hospital, Norway; Epilepsy Centre, (I.R.), Masaryk University, Hospital Ste Anne, and CEITEC-Neuroscience Centre, Brno, Czech Republic; Kuopio University Hospital and University of Eastern Finland (R.K., L.-M.V.); St. Ivan Rilski University Hospital (P.D., K. Minkin), Bulgaria; Epilepsiezentrum Kork (A.M.S., B.J.S.), Germany; Second Faculty of Medicine (A.K., P.K.,, P.M.), Charles University, Motol University Hospital, Prague, Czech Republic; Juhász Pál Epilepsy Centrum (Z.J., D.F.), National Institute of Clinical Neurosciences, Hungary; Reference Center for Refractory Epilepsy (E.C., P.B.), Ghent University Hospital, Belgium; and Department of Neurology and Neurosurgery (S. Rocka, R.M.), Vilnius University, Lithuania. margitta.seeck@hcuge.ch.
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  • 2018-06-15
Published in:
  • Neurology. - 2018
English OBJECTIVE
Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart.


METHODS
Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwent epilepsy surgery in the period of 1997 to 1998 (n = 562) or 2012 to 2013 (n = 736). Data collected included patient (sex, age) and disease (duration, localization and diagnosis) characteristics, type of surgery, histopathology, Engel postsurgical outcome, and complications, as well as imaging and electrophysiologic tests performed for each case. Postsurgical outcome predictors were included in a multivariate logistic regression to assess the strength of date of surgery as an independent predictor.


RESULTS
Over time, the number of operated cases per center increased from a median of 31 to 50 per 2-year period (p = 0.02). Mean disease duration at surgery decreased by 5.2 years (p < 0.001). Overall seizure freedom (Engel class 1) increased from 66.7% to 70.9% (adjusted p = 0.04), despite an increase in complex surgeries (extratemporal and/or MRI negative). Surgeries performed during the later period were 1.34 times (adjusted odds ratio; 95% confidence interval 1.02-1.77) more likely to yield a favorable outcome (Engel class I) than earlier surgeries, and improvement was more marked in extratemporal and MRI-negative temporal epilepsy. The rate of persistent neurologic complications remained stable (4.6%-5.3%, p = 0.7).


CONCLUSION
Improvements in European epilepsy surgery over time are modest but significant, including higher surgical volume, shorter disease duration, and improved postsurgical seizure outcomes. Early referral for evaluation is required to continue on this encouraging trend.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/156903
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