Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
-
Escott-Price V
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Bellenguez C
Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
-
Wang LS
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
-
Choi SH
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
-
Harold D
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Jones L
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Holmans P
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Gerrish A
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Vedernikov A
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Richards A
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
DeStefano AL
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
-
Lambert JC
Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
-
Ibrahim-Verbaas CA
Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
-
Naj AC
Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
-
Sims R
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Jun G
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
-
Bis JC
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
-
Beecham GW
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
-
Grenier-Boley B
Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
-
Russo G
Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
-
Thornton-Wells TA
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
-
Denning N
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Smith AV
University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
-
Chouraki V
Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
-
Thomas C
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Ikram MA
Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
-
Zelenika D
Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
-
Vardarajan BN
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
-
Kamatani Y
Fondation Jean Dausset- CEPH, Paris, France.
-
Lin CF
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
-
Schmidt H
Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
-
Kunkle B
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
-
Dunstan ML
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Vronskaya M
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Johnson AD
Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
-
Ruiz A
Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France.
-
Bihoreau MT
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
-
Reitz C
Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
-
Pasquier F
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Hollingworth P
University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France.
-
Hanon O
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America.
-
Fitzpatrick AL
Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America; Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America.
-
Buxbaum JD
CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
-
Campion D
Department of Medicine, University of Washington, Seattle, Washington, United States of America.
-
Crane PK
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America.
-
Baldwin C
German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
-
Becker T
University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
-
Gudnason V
Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
-
Cruchaga C
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
-
Craig D
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
-
Amin N
INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.
-
Berr C
Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
-
Lopez OL
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America.
-
De Jager PL
Université Lille 2, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
-
Deramecourt V
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
-
Johnston JA
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America.
-
Evans D
King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
-
Lovestone S
Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
-
Letenneur L
Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain.
-
Hernández I
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
-
Rubinsztein DC
Icelandic Heart Association, Kopavogur, Iceland.
-
Eiriksdottir G
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
-
Sleegers K
Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America.
-
Goate AM
Inserm U744, Lille, France; Institut Pasteur de Lille, Lille, France.
-
Fiévet N
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America.
-
Huentelman MJ
Discipline of Psychiatry, Trinity College, Dublin, Ireland.
-
Gill M
Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
-
Brown K
Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
-
Kamboh MI
Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
-
Keller L
King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
-
Barberger-Gateau P
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
-
McGuinness B
Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health, Seattle, Washington, United States of America.
-
Larson EB
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
-
Myers AJ
Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
-
Dufouil C
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
-
Todd S
CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
-
Wallon D
University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom.
-
Love S
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
-
Rogaeva E
Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
-
Gallacher J
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
-
George-Hyslop PS
Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
-
Clarimon J
Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain; Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.
-
Lleo A
Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
-
Bayer A
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America.
-
Tsuang DW
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.
-
Yu L
3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
-
Tsolaki M
Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
-
Bossù P
Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy.
-
Spalletta G
King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
-
Proitsi P
MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
-
Collinge J
NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
-
Sorbi S
Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
-
Garcia FS
Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
-
Fox NC
Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom.
-
Hardy J
Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
-
Naranjo MC
IRCCS Associazione Oasi Maria SS, Troina, Italy.
-
Bosco P
Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom.
-
Clarke R
Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.
-
Brayne C
University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
-
Galimberti D
University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
-
Scarpini E
Neurological Clinic, University of Pisa, Pisa, Italy.
-
Bonuccelli U
Neurological Clinic, University of Pisa, Pisa, Italy.
-
Mancuso M
Neurological Clinic, University of Pisa, Pisa, Italy.
-
Siciliano G
Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
-
Moebus S
Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
-
Mecocci P
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
-
Zompo MD
Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
-
Maier W
Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.); Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
-
Hampel H
Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
-
Pilotto A
Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto de Investigación Sanitaria "Hospital la Paz" (IdIPaz), Madrid, Spain.
-
Frank-García A
Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
-
Panza F
Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy.
-
Solfrizzi V
Department of Neuroscience-University of Parma, Parma, Italy; Center for Cognitive Disorders AUSL, Parma, Italy.
-
Caffarra P
NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
-
Nacmias B
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
-
Perry W
Department Of Psychiatry, University Hospital, Saarland, Germany.
-
Mayhaus M
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
-
Lannfelt L
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
-
Hakonarson H
Department Of Psychiatry, University Hospital, Saarland, Germany.
-
Pichler S
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
-
Carrasquillo MM
Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
-
Ingelsson M
National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America.
-
Beekly D
Genetica molecular-Huca-Oviedo, Oviedo, Spain.
-
Alvarez V
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
-
Zou F
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
-
Valladares O
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
-
Younkin SG
Genetica molecular-Huca-Oviedo, Oviedo, Spain.
-
Coto E
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America.
-
Hamilton-Nelson KL
Department of Psychiatry, University Hospital, Saarland, Germany.
-
Gu W
Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.
-
Razquin C
Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
-
Pastor P
Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
-
Mateo I
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Owen MJ
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
-
Faber KM
University of Iceland, Faculty of Medicine, Reykjavik, Iceland; Landspitali University Hospital, Reykjavik, Iceland.
-
Jonsson PV
Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
-
Combarros O
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
O'Donovan MC
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
-
Cantwell LB
Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
-
Soininen H
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America.
-
Blacker D
MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
-
Mead S
Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
-
Mosley TH
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
-
Bennett DA
Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
-
Harris TB
Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
-
Fratiglioni L
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom.
-
Holmes C
Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
-
de Bruijn RF
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
-
Passmore P
Department of Pathology, University of Washington, Seattle, Washington, United States of America.
-
Montine TJ
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
-
Bettens K
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
-
Rotter JI
INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France; AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
-
Brice A
Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
-
Morgan K
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America.
-
Foroud TM
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
-
Kukull WA
CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France.
-
Hannequin D
King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom.
-
Powell JF
Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America.
-
Nalls MA
INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Imperial College, London, United Kingdom.
-
Ritchie K
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
-
Lunetta KL
Department of Biology, Brigham Young University, Provo, Utah, United States of America.
-
Kauwe JS
Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America; Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America.
-
Boerwinkle E
Department of Psychiatry, University Hospital, Saarland, Germany.
-
Riemenschneider M
Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain; Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.
-
Boada M
Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
-
Hiltunen M
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
-
Martin ER
Department of Neurology, Medical University Graz, Graz, Austria.
-
Schmidt R
Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany.
-
Rujescu D
Inserm U897, Victor Segalen University, F-33076, Bordeaux, France; Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France.
-
Dartigues JF
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America; Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America.
-
Mayeux R
Inserm U708, Victor Segalen University, Bordeaux, France.
-
Tzourio C
Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
-
Hofman A
Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany.
-
Nöthen MM
Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden.
-
Graff C
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America.
-
Psaty BM
Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
-
Haines JL
Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Fondation Jean Dausset- CEPH, Paris, France; McGill University and Génome Québec Innovation Centre, Montreal, Canada.
-
Lathrop M
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America.
-
Pericak-Vance MA
Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America.
-
Launer LJ
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
-
Van Broeckhoven C
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America.
-
Farrer LA
Netherlands Consortium for Healthy Aging, Leiden, The Netherlands; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands.
-
van Duijn CM
Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany.
-
Ramirez A
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; The Framingham Heart Study, Framingham, Massachusetts, United States of America.
-
Seshadri S
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
-
Schellenberg GD
Inserm U744, Lille, France; Université Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France; CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France; Centre Hospitalier Régional Universitaire de Lille, Lille, France.
-
Amouyel P
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom.
-
Williams J
Show more…
English
BACKGROUND
Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
PRINCIPAL FINDINGS
In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10-6) and 14 (IGHV1-67 p = 7.9×10-8) which indexed novel susceptibility loci.
SIGNIFICANCE
The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
-
Language
-
-
Open access status
-
gold
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/global/documents/154930
Statistics
Document views: 42
File downloads: