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Enantiomer separation of alpha-ionone using gas chromatography with cyclodextrin derivatives as chiral stationary phases.
Journal article

Enantiomer separation of alpha-ionone using gas chromatography with cyclodextrin derivatives as chiral stationary phases.

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  • 2000-02-16
Published in:
  • Journal of chromatography. A. - 1999
Anesthetics, Inhalation
Chromatography, Gas
Cyclodextrins
Enflurane
Indicators and Reagents
Mathematics
Norisoprenoids
Stereoisomerism
Terpenes
English The gas chromatographic enantiomer separation of alpha-ionone was studied with three different chiral stationary phases using as chiral selectors: (1) heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin, dissolved in polysiloxane PS-086, (2) octakis(2,6-di-O-pentyl-3-O-trifluoroacetyl)-gamma-cyclodextrin and (3) octakis(2,6-di-O-pentyl-3-O-butanoyl)-gamma-cyclodextrin, both dissolved in polysiloxane SE-54. The influence of the concentration of the chiral selector in the polysiloxane, coated on Chromosorb P AW-DMCS 80-100 mesh, is described and discussed, as well as the effect of Chromosorb loading. The feasibility of the preparative gas chromatographic separation of the enantiomers of alpha-ionone is considered; in order to provide a term of comparison, the estimated performances are compared with those achieved in the separation of the enantiomers of the inhalation anaesthetic enflurane.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/153975
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