Journal article
Catalytic kinetic resolution of cyclic secondary amines.
- Binanzer M Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland.
- Hsieh SY
- Bode JW
- 2011-11-16
Published in:
- Journal of the American Chemical Society. - 2011
English
The catalytic resolution of racemic cyclic amines has been achieved by an enantioselective amidation reaction featuring an achiral N-heterocyclic carbene catalyst and a new chiral hydroxamic acid cocatalyst working in concert. The reactions proceed at room temperature, do not generate nonvolatile byproducts, and provide enantioenriched amines by aqueous extraction.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1021/ja209472h
- PMID 22082205
- Persistent URL
- https://folia.unifr.ch/global/documents/153411
Statistics
Document views: 20
File downloads: