Journal article
Molecular control of animal cell cytokinesis.
- Fededa JP Institute of Biochemistry, Swiss Federal Institute of Technology Zurich, CH-8093 Zurich, Switzerland.
- Gerlich DW
- 2012-05-04
Published in:
- Nature cell biology. - 2012
English
Cytokinesis is the process by which mitotic cells physically split in two following chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then separate the plasma membrane by abscission. The general cytological events and several conserved molecular factors involved in cytokinesis have been known for many years. However, recent progress in microscopy, chemical genetics, biochemical reconstitution and biophysical methodology has tremendously increased our understanding of the underlying molecular mechanisms. We discuss how recent insights have led to refined models of the distinct steps of animal cell cytokinesis, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission. We highlight how molecular signalling pathways coordinate the individual events to ensure faithful partitioning of the genome to emerging daughter cells.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1038/ncb2482
- PMID 22552143
- Persistent URL
- https://folia.unifr.ch/global/documents/153333
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