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ERBB receptors and cancer: the complexity of targeted inhibitors.
Journal article

ERBB receptors and cancer: the complexity of targeted inhibitors.

  • Hynes NE Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. Hynes@fmi.ch
  • Lane HA
  • 2005-05-03
Published in:
  • Nature reviews. Cancer. - 2005
Animals
Antibodies, Monoclonal
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Drug Delivery Systems
Drug Resistance, Neoplasm
Humans
Neoplasms
Receptor Protein-Tyrosine Kinases
Receptor, ErbB-2
Signal Transduction
English ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/15172
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