Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7.

• Stoyas CA Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
• Bushart DD Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
• Switonski PM Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Molecular Biomedicine, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14 Str., 61-704 Poznan, Poland.
• Ward JM Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
• Alaghatta A Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
• Tang MB Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000 Henan, China.
• Niu C Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
• Wadhwa M Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
• Huang H Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
• Savchenko A Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
• Gariani K Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
• Xie F Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
• Delaney JR Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
• Gaasterland T Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
• Auwerx J Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
• Shakkottai VG Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: vikramsh@med.umich.edu.
• La Spada AR Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: al.laspada@duke.edu.

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NAD

Purkinje neuron

calcium

cerebellum

neurodegeneration

neuronal excitability

neuroprotection

potassium channel

sirtuin

spinocerebellar ataxia

Animals

Calcium

Cell Line

Cerebellum

Female

Homeostasis

Humans

Male

Mice

Mice, Inbred C57BL

Mice, Transgenic

Neuroprotection

Niacinamide

Organ Culture Techniques

Signal Transduction

Sirtuin 1

Spinocerebellar Ataxias