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Journal article

The Transcriptional Regulation of Germinal Center Formation.

  • Song S Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
  • Matthias PD Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
  • 2018-09-21
Published in:
  • Frontiers in immunology. - 2018
B cell development
germinal center (GCs)
germinal center development
germinal center maintenance
hematopoiesis
plasma cell and memory B cell differentiation
transcription factors
transcriptional regulation
Animals
B-Lymphocytes
Carcinogenesis
Cell Differentiation
Gene Expression Regulation
Germinal Center
Humans
Immunity, Humoral
Lymphoma, B-Cell
Plasma Cells
T-Lymphocytes, Helper-Inducer
Transcription Factors
English Germinal centers (GCs) are essential structures of the humoral immune response, which form in the periphery in response to T cell dependent antigens. During the GC reaction, B cells undergo critical differentiation steps, which ultimately lead to the generation of antibodies with altered effector function and higher affinity for the selected antigen. Remarkably, many of the B cell tumors have their origin in the GCs; thus, understanding how the formation of these structures is regulated or deregulated is of high medical importance. This review gives an overview of the transcription factors that have been linked to the generation of GCs, and of their roles in the process.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/150131
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