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Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor Immunity.
Journal article

Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor Immunity.

  • Zhang L Translational Tumor Immunology Group, Ludwig Cancer Research, University of Lausanne, Lausanne, Switzerland; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland. Electronic address: Lianjun.Zhang@unil.ch.
  • Romero P Translational Tumor Immunology Group, Ludwig Cancer Research, University of Lausanne, Lausanne, Switzerland; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland. Electronic address: Pedro.Romero@unil.ch.
  • 2017-12-17
Published in:
  • Trends in molecular medicine. - 2018
Animals
CD8-Positive T-Lymphocytes
Cell Differentiation
Epigenesis, Genetic
Humans
Immunotherapy, Adoptive
Neoplasms
Organelle Biogenesis
Protein Kinases
TOR Serine-Threonine Kinases
Tumor Microenvironment
English CD8+ T cells are central players in controlling infections and cancer. Longevity, functionality, and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy. Tumor-infiltrating CD8+ T cells undergo metabolic 'exhaustion' in the nutrient- and oxygen-deprived tumor microenvironment (TME). Thus, reprograming CD8+ T cell metabolism may provide important therapeutic strategies for cancer treatment. Indeed, the adoptive transfer of memory CD8+ T cells with sustained metabolic fitness may yield better antitumor protection in both mouse models and the clinic. Here, we discuss recent progress on how cellular metabolism is linked to CD8+ T cell fate decisions and on how metabolic intermediates can impact gene expression via modulation of the epigenome. We examine the feasibility of developing potential strategies to improve antitumor immunity through the modulation of T cell metabolic activity.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/148306
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