Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.
Journal article

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

  • Patel Y Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
  • Parker N Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Shin J Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Howard D Department of Psychiatry, Yale University, New Haven, Connecticut.
  • French L Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Thomopoulos SI University of Groningen, University Medical Center Groningen, Department of Biomedical Sciences of Cells and Systems, Cognitive Neuroscience Center, Groningen, the Netherlands.
  • Pozzi E Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Spain.
  • Abe Y FIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Catalonia, Spain.
  • Abé C The Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, University of Toronto, Toronto, Ontario, Canada.
  • Anticevic A Department of Pediatrics University of Toronto, Ontario, Canada.
  • Alda M Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, Scotland.
  • Aleman A Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM.
  • Alloza C The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Alonso-Lana S Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology and Neuroscience; King's College London, London, England.
  • Ameis SH Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Anagnostou E INT UMR 7289, Aix-Marseille Université, CNRS, Aix-en-Provence, France.
  • McIntosh AA Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria; Centro de Investigación Biomédica en Red de Salud Mental, Santander, Spain.
  • Arango C Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University, the Netherlands.
  • Arnold PD Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Asherson P Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
  • Assogna F Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Auzias G The Research Institute of Pediatrics and Child Health of the Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia.
  • Ayesa-Arriola R Magnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Bakker G Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Banaj N Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
  • Banaschewski T University of Münster, Department of Psychiatry, Münster, Germany.
  • Bandeira CE Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.
  • Baranov A Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.
  • Bargalló N Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari 'Aldo Moro', Bari, Italy.
  • Bau CHD Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neuroscience, Amsterdam Neuroscience, Amsterdam, the Netherlands.
  • Baumeister S Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Psychiatry, Utrecht, the Netherlands.
  • Baune BT Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.
  • Bellgrove MA Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
  • Benedetti F University of Münster, Department of Psychiatry, Münster, Germany.
  • Bertolino A Department of Psychiatry, University of Basel, Basel, Switzerland.
  • Boedhoe PSW Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
  • Boks M McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
  • Bollettini I School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Del Mar Bonnin C Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
  • Borgers T Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Borgwardt S Department of Developmental Neuroscience - IRCCS Fondazione Stella Maris, Pisa, Italy.
  • Brandeis D Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia.
  • Brennan BP Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain.
  • Bruggemann JM FIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Catalonia, Spain.
  • Bülow R Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
  • Busatto GF School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia.
  • Calderoni S Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Calhoun VD Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, England.
  • Calvo R Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Canales-Rodríguez EJ Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, England.
  • Cannon DM Departments of Paediatrics and Psychiatry, University of Melbourne, Melbourne, Australia.
  • Carr VJ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Tübingen, Tübingen, Germany.
  • Cascella N Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Santander, Spain; Hospital Universitario Virgen del Rocío, Sevilla, Spain; Departamento de Psiquiatria, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain.
  • Cercignani M Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London UK; Zurich Center for Neuroeconomics, University of Zurich, Zurich, Switzerland.
  • Chaim-Avancini TM Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota.
  • Christakou A Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Coghill D Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, Sackler Institute for Translational Neurodevelopment, London, London, England.
  • Conzelmann A University of Münster, Department of Psychiatry, Münster, Germany.
  • Crespo-Facorro B Orygen, Melbourne, Australia.
  • Cubillo AI Department of Psychiatry, Amsterdam UMC, Amsterdam, the Netherlands.
  • Cullen KR INT UMR 7289, Aix-Marseille Université, CNRS, Aix-en-Provence, France.
  • Cupertino RB IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
  • Daly E Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
  • Dannlowski U Department of Psychology, School of Arts and Social Sciences, City, University of London, Northampton Square, Clerkenwell, London, England.
  • Davey CG University of Münster, Department of Psychiatry, Münster, Germany.
  • Denys D Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
  • Deruelle C Department of Psychiatry and Biological Sciences, Albert Einstein College of Medicine, the Bronx, New York.
  • Di Giorgio A University Medical Center Goettingen, Department of Psychiatry and Psychotherapy, Systems Neuroscience and Imaging in Psychiatry, Göettingen, Germany.
  • Dickie EW Department of Psychiatry, University of Tuebingen, Tuebingen, Germany.
  • Dima D Behavioral Neuroscience Department, Oregon Health & Science University, Portland.
  • Dohm K Department of Psychiatry, University of Tuebingen, Tuebingen, Germany.
  • Ehrlich S Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York.
  • Ely BA FIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Catalonia, Spain.
  • Erwin-Grabner T Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Ethofer T Child OCD and Anxiety Disorders Program, Department of Psychiatry, University of Michigan Medical School, Ann Arbor.
  • Fair DA San Francisco VA Medical Center, San Francisco, California.
  • Fallgatter AJ Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
  • Faraone SV University of East London, School of Psychology, London, England.
  • Fatjó-Vilas M Neuroscience Research Australia (NeuRA), Sydney, New South Wales, Australia.
  • Fedor JM Department of Neuroscience, Brighton and Sussex Medical School, Brighton, England.
  • Fitzgerald KD Tommy Fuss Center for Neuropsychiatric Disease Research, Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
  • Ford JM School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia.
  • Frodl T Central Clinical Hospital of the Russian Academy Sciences, Moscow, Russia.
  • Fu CHY Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
  • Fullerton JM Department of Psychology, Stanford University, Stanford, California.
  • Gabel MC University Medical Center Goettingen, Department of Psychiatry and Psychotherapy, Systems Neuroscience and Imaging in Psychiatry, Göettingen, Germany.
  • Glahn DC Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
  • Roberts G School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia.
  • Gogberashvili T Department of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Goikolea JM Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
  • Gotlib IH University of Münster, Department of Psychiatry, Münster, Germany.
  • Goya-Maldonado R Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
  • Grabe HJ Department of Psychiatry, Yale University, New Haven, Connecticut.
  • Green MJ FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Grevet EH Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
  • Groenewold NA Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
  • Grotegerd D Department of Bioengineering, Imperial College London, London, England.
  • Gruber O Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Gruner P Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Guerrero-Pedraza A University of Münster, Department of Psychiatry, Münster, Germany.
  • Gur RE Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Gur RC Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia.
  • Haar S Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, England.
  • Haarman BCM University of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), Groningen, the Netherlands.
  • Haavik J Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, Scotland.
  • Hahn T Department of Experimental Psychology, Vrije Universiteit, Amsterdam, Netherlands.
  • Hajek T Genentech Inc, South San Francisco, California.
  • Harrison BJ Department of Psychology, University of Oslo, Oslo, Norway.
  • Harrison NA Research Center for Child Mental Development, Chiba University, Chiba, Japan.
  • Hartman CA Department of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco.
  • Whalley HC University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, the Netherlands.
  • Heslenfeld DJ Radboud University Medical Center, Karakter University Center of Child And Adolescent Psychiatry, Nijmegen, the Netherlands.
  • Hibar DP Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
  • Hilland E Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland.
  • Hirano Y National Institute of Mental Health, Klecany, Czech Republic.
  • Ho TC Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  • Hoekstra PJ Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Hoekstra L Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
  • Hohmann S Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Hong LE University of Oxford, Oxford, England.
  • Höschl C Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Spain.
  • Høvik MF Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
  • Howells FM Department of Internal Medicine, First Affiliated Hospital of Kunming Medical University, Kunming. China.
  • Nenadic I Department of Psychology, University of Oslo, Oslo, Norway.
  • Jalbrzikowski M Research Institute of Pediatrics and child health of the Central clinical hospital of the Ministry of Science and Education, Moscow, Russia.
  • James AC Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
  • Janssen J Department of Psychiatry, Philipps-University Marburg, Marburg, Germany.
  • Jaspers-Fayer F Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
  • Xu J Department of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
  • Jonassen R Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland.
  • Karkashadze G Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital RWTH Aachen, Aachen, Germany.
  • King JA Child Neuropsychology Section, University Hospital RWTH Aachen, German; JARA-Brain Institute II Molecular Neuroscience and Neuroimaging, Research Centre Juelich, Juelich, Germany.
  • Kircher T Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
  • Kirschner M Department of Psychiatry, Philipps-University Marburg, Marburg, Germany.
  • Koch K Social, Genetic and Developmental Psychiatry Centre; Institute of Psychiatry, Psychology and Neuroscience; King's College London, London, England.
  • Kochunov P Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
  • Kohls G Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Konrad K Department of Psychology, University of Oslo, Oslo, Norway.
  • Krämer B Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain.
  • Krug A Mental Health Research Center, Moscow, Russia.
  • Kuntsi J University of Münster, Department of Psychiatry, Münster, Germany.
  • Kwon JS Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain.
  • Landén M Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
  • Landrø NI SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
  • Lazaro L Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.
  • Lebedeva IS Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Leehr EJ Department of Biological and Medical psychology, University of Bergen, Bergen, Norway.
  • Lera-Miguel S Departments of Psychiatry and Pediatrics, University of Calgary, Calgary, Alberta, Canada.
  • Lesch KP University Centre for Information Technology, University of Oslo, Oslo, Norway.
  • Lochner C Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia.
  • Louza MR Group of Research in Mental Health, Institut d'Investigació Biomèdica Sant Pau, IIBSant Pau; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
  • Luna B Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
  • Lundervold AJ Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
  • MacMaster FP Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Maglanoc LA Department of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco.
  • Malpas CB Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.
  • Portella MJ Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
  • Marsh R Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
  • Martyn FM University of Münster, Department of Psychiatry, Münster, Germany.
  • Mataix-Cols D Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
  • Mathalon DH McMaster University, Mood Disorders Program, SJH Hamilton, Hamilton, Ontario, Canada.
  • McCarthy H School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia.
  • McDonald C Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM.
  • McPhilemey G Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
  • Meinert S Department of Developmental Neuroscience - IRCCS Fondazione Stella Maris, Pisa, Italy.
  • Menchón JM Department of Forensic and Neurodevelopmental Science, King's College London, London, England.
  • Minuzzi L Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College, London, England.
  • Mitchell PB Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston.
  • Moreno C Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
  • Morgado P Research Center for Child Mental Development, Chiba University, Chiba, Japan.
  • Muratori F Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Murphy CM The Research Institute of Pediatrics and Child Health of the Central Clinical Hospital of the Russian Academy of Sciences of the Ministry of Science and Higher Education of the Russian Federation, Moscow, Russia.
  • Murphy D OCD clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
  • Mwangi B Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles.
  • Nabulsi L Department of Pediatrics, University of California, Irvine.
  • Nakagawa A Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain.
  • Nakamae T Center for MR Research, University Children's Hospital, Zürich, Switzerland.
  • Namazova L Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  • Narayanaswamy J Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, department of Pediatrics, Amsterdam Reproduction and Development, Amsterdam, the Netherlands.
  • Jahanshad N University of Münster, Department of Psychiatry, Münster, Germany.
  • Nguyen DD Center for Neurobehavioral Genetics, University of California Los Angeles.
  • Nicolau R Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • O'Gorman Tuura RL Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Santander, Spain.
  • O'Hearn K Neuroscience Research Australia, Sydney, Australia.
  • Oosterlaan J Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, England.
  • Opel N Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia.
  • Ophoff RA Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM.
  • Oranje B Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), and Center of Mental Health, University of Würzburg, Würzburg, Germany.
  • García de la Foz VO Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
  • Overs BJ Department of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Paloyelis Y Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Pantelis C Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
  • Parellada M Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland; Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark, Denmark.
  • Pauli P FIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Catalonia, Spain.
  • Picó-Pérez M Department of Psychiatry and Human Behavior, University of California, Irvine.
  • Picon FA Department of Child and Adolescent Psychiatry and Psychology, Hospital Clinic, Barcelona, Spain.
  • Piras F School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia.
  • Piras F Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona Bipolar Disorders and Depressive Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
  • Plessen KJ Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain; Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute, Barcelona, Catalonia, Spain; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
  • Pomarol-Clotet E Priority Centre for Brain & Mental Health Research, The University of Newcastle, Callaghan, New South Wales, Australia.
  • Preda A Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
  • Puig O OCD clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
  • Quidé Y University of Münster, Department of Psychiatry, Münster, Germany.
  • Radua J Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany.
  • Ramos-Quiroga JA Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Rasser PE University of Münster, Department of Psychiatry, Münster, Germany.
  • Rauer L National Institute for Nuclear Physics, Pisa Division, Pisa, Italy.
  • Reddy J Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain; Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute, Barcelona, Catalonia, Spain; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
  • Redlich R Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
  • Reif A Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Reneman L Department of Child & Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
  • Repple J Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Retico A Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
  • Richarte V FIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Catalonia, Spain.
  • Richter A Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Facultad de Psicologia, Universidad Autónoma de Madrid.
  • Rosa PGP University of Münster, Department of Psychiatry, Münster, Germany.
  • Rubia KK FIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Catalonia, Spain.
  • Hashimoto R Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
  • Sacchet MD Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Salvador R Priority Centre for Brain & Mental Health Research, The University of Newcastle, Callaghan, New South Wales, Australia.
  • Santonja J Neuroscience Research Australia, Sydney, New South Wales, Australia.
  • Sarink K Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Sarró S Department of Child and Adolescent Psychiatry, RWTH Aachen University Hospital, Aachen, Germany.
  • Satterthwaite TD Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Sawa A Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria; Centro de Investigación Biomédica en Red de Salud Mental, Santander, Spain.
  • Schall U National Human Genome Research Institute and National Institute of Mental Health, Bethesda, Maryland.
  • Schofield PR Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Schrantee A School of Psychology, Deakin University, Geelong, Melbourne, Australia.
  • Seitz J West Region, Institute of Mental Health, Singapore.
  • Serpa MH Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
  • Setién-Suero E Columbia University Irving Medical Center, New York, New York.
  • Shaw P University Medical Center Goettingen, Department of Psychiatry and Psychotherapy, Systems Neuroscience and Imaging in Psychiatry, Göettingen, Germany.
  • Shook D National Institute of Mental Health, Klecany, Czech Republic.
  • Silk TJ Center for Child and Adolescent Mental Health, Institute of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
  • Sim K Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston.
  • Simon S Pediatric OCD Consultation Clinic, Anxiety Treatment and Research Center, SJH Hamilton, Ontario, Canada.
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Show more…
  • 2020-08-29
Published in:
  • JAMA psychiatry. - 2020
English Importance
Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.


Objective
To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia.


Design, Setting, and Participants
Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244.


Main Outcomes and Measures
Interregional profiles of group difference in cortical thickness between cases and controls.


Results
A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders.


Conclusions and Relevance
In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/144471
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