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Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.

  • Mohty M Hematology Department, Hôpital Saint Antoine, and Université Pierre & Marie Curie, Paris, France.
  • Malard F Hematology Department, Hôpital Saint Antoine, and Université Pierre & Marie Curie, Paris, France.
  • Abecassis M Instituto Portugues de Oncologia, Lisbon, Portugal.
  • Aerts E Department of Haematology, University Hospital Zurich, Zurich, Switzerland.
  • Alaskar AS King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
  • Aljurf M King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  • Arat M Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
  • Bader P Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
  • Baron F Department of Hematology, University of Liege, Liege, Belgium.
  • Bazarbachi A Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
  • Blaise D Blood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
  • Ciceri F Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
  • Corbacioglu S Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
  • Dalle JH Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
  • Dignan F Department of Clinical Haematology, Central Manchester Foundation Trust, Manchester, UK.
  • Fukuda T HSCT division, National Cancer Center Hospital, Tokyo, Japan.
  • Huynh A Hematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
  • Masszi T Department of Hematology and Stem Cell Transplantation, St Istvan and St Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
  • Michallet M Hematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
  • Nagler A Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
  • NiChonghaile M National Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
  • Okamoto S Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Pagliuca A Department of Haematology, King's College Hospital, London, UK.
  • Peters C Department of Pediatrics, St Anna Kinderspital, Vienna, Austria.
  • Petersen FB LDS Hospital, Salt Lake City, UT, USA.
  • Richardson PG Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ruutu T Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.
  • Savani BN Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee.
  • Wallhult E Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg Sweden.
  • Yakoub-Agha I CHU de Lille, LIRIC INSERM U995, université de Lille2, France.
  • Duarte RF Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Carreras E Josep Carreras Foundation & Leukemia Research Institute, Hematology Department, Hospital Clínic, Barcelona, Spain.
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  • 2016-05-17
Published in:
  • Bone marrow transplantation. - 2016
Adult
Biomarkers
Early Diagnosis
Hematopoietic Stem Cell Transplantation
Hepatic Veno-Occlusive Disease
Humans
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
English Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.
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  • English
Open access status
hybrid
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Persistent URL
https://folia.unifr.ch/global/documents/141886
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