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Immunology of Alveolar and Cystic Echinococcosis (AE and CE).
Journal article

Immunology of Alveolar and Cystic Echinococcosis (AE and CE).

  • Gottstein B University of Bern, Bern, Switzerland.
  • Soboslay P University of Tübingen, Tübingen, Germany.
  • Ortona E Istituto Superiore di Sanità, Rome, Italy.
  • Wang J University of Bern, Bern, Switzerland.
  • Siracusano A Istituto Superiore di Sanità, Rome, Italy.
  • Vuitton DΑ WHO Collaborating Centre, Université de Franche-Comté, Besançon, France.
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  • 2017-02-19
Published in:
  • Advances in parasitology. - 2017
Alveolar echinococcosis
Cystic echinococcosis
Dendritic cells
Fibrinogen-like protein 2
Macrophages
Regulatory T cells
TGF-β
Vaccination
Animals
Echinococcosis
Echinococcosis, Hepatic
Echinococcus granulosus
Echinococcus multilocularis
Host-Parasite Interactions
Humans
English Cystic and alveolar echinococcosis are severe chronic helminthic diseases caused by the cystic growth or the intrahepatic tumour-like growth of the metacestode of Echinococcus granulosus or Echinococcus multilocularis, respectively. Both parasites have evolved sophisticated strategies to escape host immune responses, mainly by manipulating and directing this immune response towards anergy and/or tolerance. Recent research studies have revealed a number of respective immunoregulatory mechanisms related to macrophages and dendritic cell as well as T cell activities (regulatory T cells, Tregs). A better understanding of this complex parasite-host relationship, and the elucidation of specific crucial events that lead to disease, represents targets towards the development of novel treatment strategies and options.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/140571
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