Journal article
Descriptive epidemiology of parkinsonism in the Canton of Geneva, Switzerland.
- Fleury V Department of Neurology, Geneva University Hospital, 1211 Geneva 14, Switzerland; Faculty of Medicine, University of Geneva, CMU, 1211 Geneva 4, Switzerland. Electronic address: Vanessa.FleuryNissen@hcuge.ch.
- Brindel P Department of Health and Community Medicine, Geneva University Hospital, 1211 Geneva 14, Switzerland.
- Nicastro N Division of Neurorehabilitation, Geneva University Hospital, 1206 Geneva, Switzerland.
- Burkhard PR Department of Neurology, Geneva University Hospital, 1211 Geneva 14, Switzerland; Faculty of Medicine, University of Geneva, CMU, 1211 Geneva 4, Switzerland.
- 2018-04-18
Published in:
- Parkinsonism & related disorders. - 2018
Epidemiology
Incidence
Parkinson's disease
Parkinsonism
Prevalence
Aged
Aged, 80 and over
Cross-Sectional Studies
Female
Humans
Incidence
Lewy Body Disease
Male
Middle Aged
Multiple System Atrophy
Parkinson Disease
Parkinsonian Disorders
Prevalence
Retrospective Studies
Supranuclear Palsy, Progressive
Switzerland
English
OBJECTIVES
A large descriptive cross-sectional population-based prevalence study as well as a retrospective incidence study were undertaken to ascertain the frequency of Parkinson's Disease (PD) and other types of degenerative and non-degenerative parkinsonism in the Canton of Geneva, Switzerland.
METHODS
An extensive case-finding approach including records from public hospitals, private neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism established between 2003 and 2012 were included. Diagnosis of parkinsonism was ascertained by a movement disorders specialist, based on published and validated consensus diagnostic criteria.
RESULTS
A total of 1235 living patients with parkinsonism were identified, from which 80% presented with a degenerative form and 20% with a non-degenerative form of parkinsonism. Among the former, PD was the most frequent diagnosis (81%, age-adjusted prevalence: 183/105 inhabitants, age-adjusted average annual incidence: 20/105/year) followed by dementia with Lewy bodies (9%), progressive supranuclear palsy (3.9%), multisystem atrophy (1.9%) and corticobasal syndrome (1.4%). Among non-degenerative parkinsonism, drug-induced parkinsonism was the most frequent diagnosis (43.4%), followed by vascular parkinsonism (37%), normal pressure hydrocephalus (5.1%) and parkinsonism in the context of a psychiatric disorder or functional parkinsonism (3.8%). Crude, age-, sex-specific and age-adjusted prevalence and incidence of all types of parkinsonism are detailed for each diagnosis.
CONCLUSION
This is the first Swiss population-based epidemiological study of PD and parkinsonism. It provides an extensive overview of the prevalence and incidence of degenerative and non-degenerative forms of parkinsonism. These data may assist clinicians with their clinical workup.
A large descriptive cross-sectional population-based prevalence study as well as a retrospective incidence study were undertaken to ascertain the frequency of Parkinson's Disease (PD) and other types of degenerative and non-degenerative parkinsonism in the Canton of Geneva, Switzerland.
METHODS
An extensive case-finding approach including records from public hospitals, private neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism established between 2003 and 2012 were included. Diagnosis of parkinsonism was ascertained by a movement disorders specialist, based on published and validated consensus diagnostic criteria.
RESULTS
A total of 1235 living patients with parkinsonism were identified, from which 80% presented with a degenerative form and 20% with a non-degenerative form of parkinsonism. Among the former, PD was the most frequent diagnosis (81%, age-adjusted prevalence: 183/105 inhabitants, age-adjusted average annual incidence: 20/105/year) followed by dementia with Lewy bodies (9%), progressive supranuclear palsy (3.9%), multisystem atrophy (1.9%) and corticobasal syndrome (1.4%). Among non-degenerative parkinsonism, drug-induced parkinsonism was the most frequent diagnosis (43.4%), followed by vascular parkinsonism (37%), normal pressure hydrocephalus (5.1%) and parkinsonism in the context of a psychiatric disorder or functional parkinsonism (3.8%). Crude, age-, sex-specific and age-adjusted prevalence and incidence of all types of parkinsonism are detailed for each diagnosis.
CONCLUSION
This is the first Swiss population-based epidemiological study of PD and parkinsonism. It provides an extensive overview of the prevalence and incidence of degenerative and non-degenerative forms of parkinsonism. These data may assist clinicians with their clinical workup.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.parkreldis.2018.03.030
- PMID 29661694
- Persistent URL
- https://folia.unifr.ch/global/documents/137955
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