Journal article
Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats.
- Gadient RA Department of Physiology, University of Basel, Switzerland.
- Otten U
- 1994-12-05
Published in:
- Neuroscience letters. - 1994
Animals
Cerebellum
Gene Expression
Hippocampus
In Situ Hybridization
Interleukin-6
Male
Neurons
Purkinje Cells
RNA, Messenger
Rats
English
The cellular source of interleukin-6 (IL-6) in brain has not been identified. Using a sensitive, non-radioactive in situ hybridization technique, the cellular localization of IL-6 mRNA in different areas of the rat brain was analysed. Intense staining for IL-6 mRNA was found in Purkinje cells and hippocampal neurons. Our data support an essential role of IL-6 for cerebellar and hippocampal neuron differentiation and function.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0304-3940(94)90807-9
- PMID 7715819
- Persistent URL
- https://folia.unifr.ch/global/documents/137224
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