The instructive role of dendritic cells on T-cell responses.
- Sallusto F Institute for Research in Biomedicine, Bellinzona, Switzerland.
- Lanzavecchia A
- 2002-07-12
Published in:
- Arthritis research. - 2002
English
Immune responses are initiated in the T-cell areas of secondary lymphoid organs where naïve T lymphocytes encounter dendritic cells (DCs) that present antigens taken up in peripheral tissues. DCs represent the interface between the universe of foreign and tissue-specific antigens and T lymphocytes, and they are the key players in the regulation of cell-mediated immunity. We discuss how the nature of the DC maturation stimuli and the density and quality of DCs present in the T-cell areas of secondary lymphoid organs determine the magnitude and class of the T-cell response.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1186/ar567
- PMID 12110131
- Persistent URL
- https://folia.unifr.ch/global/documents/13589
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