Back
Full-text
Journal article

Detection of Cu2+ Ions with GGH Peptide Realized with Si-Nanoribbon ISFET.

  • Synhaivska O Transport at Nanoscale Interfaces Laboratory, Empa-Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600 Duebendorf, Switzerland. olena.synhaivska@empa.ch.
  • Mermoud Y Transport at Nanoscale Interfaces Laboratory, Empa-Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600 Duebendorf, Switzerland. yves.mermoud@empa.ch.
  • Baghernejad M Transport at Nanoscale Interfaces Laboratory, Empa-Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600 Duebendorf, Switzerland. baghernejad@mpip-mainz.mpg.de.
  • Alshanski I Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel. israel.alshanski@mail.huji.ac.il.
  • Hurevich M Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel. mattan.hurevich@mail.huji.ac.il.
  • Yitzchaik S Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel. shlomo.yitzchaik@mail.huji.ac.il.
  • Wipf M Transport at Nanoscale Interfaces Laboratory, Empa-Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600 Duebendorf, Switzerland. mathias.wipf@empa.ch.
  • Calame M Transport at Nanoscale Interfaces Laboratory, Empa-Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600 Duebendorf, Switzerland. michel.calame@empa.ch.
Show more…
  • 2019-09-22
Published in:
  • Sensors (Basel, Switzerland). - 2019
GGH peptide
copper
ion-sensitive field effect transistor
potentiometric sensing
silicon nanoribbons
English The presence of heavy metal ions such as copper in the human body at certain concentrations and specific conditions can lead to the development of different diseases. The currently available analytical detection methods remain expensive, time-consuming, and often require sample pre-treatment. The development of specific and quantitative, easy-in-operation, and cost-effective devices, capable of monitoring the level of Cu2+ ions in environmental and physiological media, is necessary. We use silicon nanoribbon (SiNR) ion-sensitive field effect transistor (ISFET) devices modified with a Gly-Gly-His peptide for the detection of copper ions in a large concentration range. The specific binding of copper ions causes a conformational change of the ligand, and a deprotonation of secondary amine groups. By performing differential measurements, we gain a deeper insight into the details of the ion-ligand interaction. We highlight in particular the importance of considering non-specific interactions to explain the sensors' response.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/13559
Statistics
Document views: 30 File downloads:
  • Full-text: 0